Rat Anti-Human Jak1 | MyBioSource MBS692342 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rat Anti-Human Jak1

catalog :

MBS692342

quantity :

0.1 mg

price :

490 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

[33N17]

reactivity :

human

application :

western blot, immunohistochemistry, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS692342

products type :

Antibody

products full name :

Rat Anti-Human Jak1

products short name :

[Jak1]

products name syn :

[JAK1A, JAK1B, Janus kinase1, Tyrosine-protein kinase JAK1]

other names :

[tyrosine-protein kinase JAK1 isoform 1; Tyrosine-protein kinase JAK1; tyrosine-protein kinase JAK1; Janus kinase 1; Janus kinase 1; JAK-1]

products gene name :

[Jak1]

other gene names :

[JAK1; JAK1; JTK3; JAK1A; JAK1B; JAK1A; JAK1B; JAK-1]

clonality :

Monoclonal

isotype :

IgG2

clone :

[33N17]

host :

Rat

reactivity :

Human

sequence length :

1154

specificity :

This antibody was selected for its ability to detect human VEGF165b. The antibody showed no cross reactivity with rh VEGF206

purity :

Protein G chromatography

form :

Lyophilized

concentration :

Preparation This antibody was produced from a hybridoma (rat myeloma fused with spleen cells from a rat) immunized with Recombinant human Jak1. IgG2 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.

storage stability :

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.Shipping: Ships at RT or 4°C

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

app notes :

WB: 1:500-1:1000. IHC: 1:20-1:100. FC

other info1 :

Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. Antigen: Recombinant human Jak1

products description :

VEGF165b is an mRNA splice variant of VEGF. Alternative exon usage results in a 165 aa product that is identical to VEGF165 except for 6 unique amino acids at the C-terminus. VEGF165b inhibits proliferation and migration of endothelial cells and id down-regulated in renal cell carcinoma.

ncbi gi num :

1004007314

ncbi acc num :

NP_001307852.1

ncbi gb acc num :

NM_001320923.1

uniprot acc num :

P23458

ncbi mol weight :

133,277 Da

ncbi pathways :

ARMS-mediated Activation Pathway (1269471); Antiviral Mechanism By IFN-stimulated Genes Pathway (1269316); Axon Guidance Pathway (1270303); Cytokine Signaling In Immune System Pathway (1269310); DAP12 Interactions Pathway (1269283); DAP12 Signaling Pathway (1269284); Developmental Biology Pathway (1270302); Downstream Signal Transduction Pathway (1269479); EGF/EGFR Signaling Pathway (198782); EGFR Tyrosine Kinase Inhibitor Resistance Pathway (1404798)

ncbi summary :

This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

uniprot summary :

JAK1: a widely expressed non-receptor tyrosine-kinase involved in the interferon-alpha/beta and -gamma signal transduction pathways. Couples cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. A selective Jak1 inhibitor induces apoptosis in NRP-154 prostate cancer cell line. A single mutation seen in tyrosine kinome screen of colon cancers. Activated in B cell lines from patients with post-transplant lymphoproliferative disorder, and in a mouse Lck-driven T cell lymphoma. Inhibitor: Piceatannol. Protein type: EC 2.7.10.2; JakA family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group. Chromosomal Location of Human Ortholog: 1p31.3. Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; nucleus. Molecular Function: growth hormone receptor binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein phosphatase binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding; ubiquitin protein ligase binding. Biological Process: cell differentiation; cell migration; innate immune response; MAPKKK cascade; protein amino acid phosphorylation; regulation of cell proliferation; response to antibiotic; transmembrane receptor protein tyrosine kinase signaling pathway

size1 :

0.1 mg

price1 :

490 USD

more info or order :

MyBioSource product webpage