product summary
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company name :
MyBioSource
product type :
protein
product name :
Human IGF-BP2
catalog :
MBS692085
quantity :
0.005 mg
price :
200 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS692085
products type :
Recombinant Protein
products full name :
Human IGF-BP2
products short name :
[IGF-BP2]
products name syn :
[Recombinant Human IGF-BP-2]
other names :
[insulin-like growth factor-binding protein 2; Insulin-like growth factor-binding protein 2; insulin-like growth factor-binding protein 2; IBP-2; IGFBP-2; IGF-binding protein 2; insulin-like growth factor binding protein 2, 36kDa]
products gene name :
[IGF-BP2]
other gene names :
[IGFBP2; IGFBP2; IBP2; IGF-BP53; BP2; IBP2; IBP-2; IGF-binding protein 2; IGFBP-2]
uniprot entry name :
IBP2_HUMAN
host :
Insect Cells
reactivity :
Human
sequence length :
289
sequence :
EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREP GCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM G EGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGG GSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KL RPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKH GL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLF YNEQQEA RGVHTQRMQ
purity :
> 98% by SDS-PAGE & HPLC analyses
form :
Lyophilized
storage stability :
The lyophilized protein is stable at room temperature for 1 month and at 4 degree C for 6 months. Reconstituted working aliquots are stable for 1 week at 2 degree C to 8 degree C and for 3 months at -20 degree C to -80 degree C. Avoid repeated freeze and thaw cycles.
other info1 :
Endotoxin Level: < 0.1 ng/ug of protein (1<1EU/ug).
other info2 :
Biological Activity: Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells. Reconstitution: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/m. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree to -80 degree C.
products categories :
Cytokines & Growth Factors
products description :
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
ncbi gi num :
55925576
ncbi acc num :
NP_000588.2
ncbi gb acc num :
NM_000597.2
uniprot acc num :
P18065
ncbi mol weight :
31.5 kDa
ncbi pathways :
Metabolism Of Proteins Pathway (106230); Myometrial Relaxation And Contraction Pathways (198759); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908)
uniprot summary :
Function: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Ref.11. Subunit structure: Binds IGF2 more than IGF1. Subcellular location: Secreted. Domain: The C-terminus is required for IGF-binding and growth inhibition. Ref.11. Post-translational modification: O-glycosylated. Ref.10. Sequence similarities: Contains 1 IGFBP N-terminal domain.Contains 1 thyroglobulin type-1 domain.
size1 :
0.005 mg
price1 :
200 USD
size2 :
0.02 mg
price2 :
340
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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