product summary
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company name :
MyBioSource
product type :
protein
product name :
Human MIA (Melanoma inhibitory activity)
catalog :
MBS691728
quantity :
0.02 mg
price :
380 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS691728
products type :
Recombinant Protein
products full name :
Human MIA (Melanoma inhibitory activity)
products short name :
MIA (Melanoma inhibitory activity)
products name syn :
Recombinant Human MIA
other names :
melanoma-derived growth regulatory protein; Melanoma-derived growth regulatory protein; melanoma-derived growth regulatory protein; melanoma inhibitory activity; Melanoma inhibitory activity protein
products gene name :
MIA
other gene names :
MIA; MIA; CD-RAP
uniprot entry name :
MIA_HUMAN
host :
E Coli
reactivity :
Human
sequence length :
131
sequence :
MGPMPKLADR KLCADQECSH PISMAVALQD YMAPDCRFLT IHRGQV VYVF SKLKGRGRLF WGGSVQGDYY GDLAARLGYF PSSIVREDQT L KPGKVDVKT DKWDFYCQ
purity :
> 98% by SDS-PAGE and HPLC analysis
form :
Lyophilized
other info1 :
Endotoxin Level: < 0.1 ng per ug of MIA
other info2 :
Biological Activity: The ED50 was determined by the dose-dependant proliferation of the human A375 melanoma cell line. The expected ED50 for this effect is 4-6 ug/ml.
products categories :
Cytokines & Growth Factors
products description :
MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family; MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis. Recombinant human MIA is a 12.2 kDa globular protein containing 108 amino acid residues including two intramolecular disulfide bonds.
ncbi gi num :
321400133
ncbi acc num :
NP_001189482.1
ncbi gb acc num :
NM_001202553.1
uniprot acc num :
Q16674
ncbi mol weight :
12.2 kDa
ncbi pathways :
Neural Crest Differentiation Pathway 672460
uniprot summary :
Function: Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas. Subunit structure: Interacts with FASLG. Interacts with TMIGD2. Ref.9 Ref.10. Subcellular location: Secreted. Tissue specificity: All malignant melanoma cell lines tested and infrequently in glioma cell lines. Post-translational modification: May possess two intramolecular disulfide bonds. Sequence similarities: Belongs to the MIA/OTOR family.Contains 1 SH3 domain.
size :
0.02 mg
price :
380 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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