Human Galectin-1 | MyBioSource MBS691583 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human Galectin-1

catalog :

MBS691583

quantity :

0.05 mg

price :

280 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS691583

products type :

Recombinant Protein

products full name :

Human Galectin-1

products short name :

Galectin-1

products name syn :

Recombinant Human Galectin-1

other names :

galectin-1; Galectin-1; galectin-1; HBL; HPL; gal-1; HLBP14; galaptin; galectin 1; 14 kDa lectin; S-Lac lectin 1; lactose-binding lectin 1; 14 kDa laminin-binding protein; putative MAPK-activating protein PM12; beta-galactoside-binding lectin L-14-I; beta-galactoside-binding protein 14kDa; lectin, galactoside-binding, soluble, 1; 14 kDa laminin-binding protein; HLBP14; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; Galaptin; HBL; HPL; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; Putative MAPK-activating protein PM12; S-Lac lectin 1

other gene names :

LGALS1; LGALS1; GBP; GAL1; Gal-1; HLBP14

uniprot entry name :

LEG1_HUMAN

host :

E Coli

reactivity :

Human

sequence length :

134

sequence :

ACGLVASNLN LKPGECLRVR GEVAPDAKSF VLNLGKDSNN LCLHFNPRFN AHGDANTIVC NSKDGGAWGT EQREAVFPFQ PGSVAEVCIT FDQANLTVKL PDGYEFKFPN RLNLEAINYM AADGDFKIKC VAFD. Result by N-terminal sequencing:ACGLVASNLNLKPGE

purity :

>98% by SDS-PAGE & Coomassie stain

form :

lyophilized

storage stability :

The lyophilized human Galectin-l, though stable at room temperature, is best stored desiccated below O degree C. Reconstituted human Galectin-I should be stored in working aliquots at -20 degree C . Avoid repeated freeze and thaw cycles!

other info1 :

Endotoxin Level: < 0.1 ng per ug of Galectin-1

other info2 :

Biological Activity: Determine by its ability to chemoattract human blood monocytes. Chemotactic activity was observed at a concentration of 2.5 ug/ml with a peak response obatined at 250 ug/ml. Reconstitution: Human Galectin-I should be reconstituted in water to a concentration of 0.1 mg/mI. This solution can be diluted in water or other buffer solutions or stored at -20 degree C. Buffer: PBS. Stabilizer: None

products categories :

Cytokines & Growth Factors

products description :

Lectins, of either plant or animal ongm, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. Galectin-I (Gal-I) is one of 15 evolutionarily conserved 13-galactoside-binding proteins that display biologicallydiverse activities in pathogenesis of inflammation and cancer. Gal-I is variably expressed on immune cells and endothelial cells, though is commonly found and secreted at high levels in cancer cells. There is also compelling evidence in models of cancer and autoimmunity that recombinant Gal-I (rGal-l) can potentiate immunoregulatory function of T cells. Galectin-I is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-Ieukemia cell lines through homodimeric binding of Nacetyllactosamines on membrane glycoproteins (Gal-l ligands) and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-l is a 14.5 kDa protein containing 134 amino acid residues.

ncbi gi num :

4504981

ncbi acc num :

NP_002296.1

ncbi gb acc num :

NM_002305.3

uniprot acc num :

P09382

ncbi mol weight :

~14 kDa

ncbi pathways :

Validated Targets Of C-MYC Transcriptional Repression Pathway (169353)

ncbi summary :

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Ref.24 Ref.26 Ref.31. Subunit structure: Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Ref.18 Ref.23 Ref.30 Ref.31. Subcellular location: Secreted extracellular space extracellular matrix Ref.24. Tissue specificity: Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. Ref.4 Ref.26. Sequence similarities: Contains 1 galectin domain.

size1 :

0.05 mg

price1 :

280 USD

more info or order :

MyBioSource product webpage