protein

Mouse IFN-gamma

MBS691575

0.02 mg

200 USD

Recombinant Protein

Mouse IFN-gamma

[IFN-gamma]

[Recombinant Murine IFN-gamma , Ifng, Ifg, IFN-g]

[interferon gamma; Interferon gamma; interferon gamma; IFN-gamma; gamma interferon; interferon gamma]

[IFN-gamma]

[Ifng; Ifng; Ifg; IFN-g; IFN-gamma]

IFNG_MOUSE

E Coli

Mouse

134

MHGTVIESLE SLNNYFNSSG IDVEEKSLFL DIWRNWQKDG DMKILQ SQII SFYLRLFEVL KDNQAISNNI SVIESHLITT FFSNSKAKKD A FMSIAKFEV NNPQVQRQAF NELIRVVHQL LPESSLRKRK RSRC

> 98% by SDS-PAGE & HPLC analyses

Lyophilized

The lyophilized protein is stable at room temperature for 1 month and at 4°C for 6 months. Reconstituted working aliquots are stable for 1 week at 2°C to 8°C and for 12 months at -20°C to -80°C.

Endotoxin Level: = 5 x 10^6 units/mg. Length: 134

Reconstitution: Centrifuge vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/m. Do not vortex. This solution can be stored at 2°C to 8°C for up to 1 week. For extended storage it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Cytokines & Growth Factors

IFN-gamma is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-gamma receptors are present in most immune cells, which respond to IFN-gamma signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-gamma signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulates the antigen-specific phases of the immune response. Additionally, IFN-gamma stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-gamma species-specific and is biologically active only in human and primate cells. Recombinant murine IFN-gamma is a 15.6 kDa protein containing 134 amino acid residues.

33468859

NP_032363.1

NM_008337.3

P01580

15.6 kDa

African Trypanosomiasis Pathway (194387); African Trypanosomiasis Pathway (194323); Allograft Rejection Pathway (83316); Allograft Rejection Pathway (535); Amoebiasis Pathway (167330); Amoebiasis Pathway (167191); Antigen Processing And Presentation Pathway (83271); Antigen Processing And Presentation Pathway (485); Chagas Disease (American Trypanosomiasis) Pathway (147810); Chagas Disease (American Trypanosomiasis) Pathway (147795)

This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of the both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial inflections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Sep 2015]

Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Subunit structure: Homodimer. Subcellular location: Secreted. Tissue specificity: Released primarily from activated T lymphocytes. Sequence similarities: Belongs to the type II (or gamma) interferon family.

0.02 mg

200 USD

0.1 mg

340