product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit Anti-Bovine SRY
catalog :
MBS691302
quantity :
0.1 mg
price :
280 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
cow
application :
western blot
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS691302
products type :
Antibody
products full name :
Rabbit Anti-Bovine SRY
products short name :
SRY
products name syn :
Anti-bovine SRY; Sex-determining region Y protein; Testis-determining factor
other names :
sex-determining region Y protein; Sex-determining region Y protein; sex-determining region Y protein; sex determining factor Y; testis-determining factor; sex-determining region of the Y-chromosome; Testis-determining factor
products gene name :
SRY
other gene names :
SRY; SRY; TDF
uniprot entry name :
SRY_BOVIN
clonality :
Polyclonal
clone :
Rabbit IgG
host :
Rabbit
reactivity :
Bovine
sequence length :
229
purity :
Protein A purified
form :
Lyophilized
storage stability :
The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 degree C. Frozen aliquots are stable for at least 6 months when stored at -20 degree C.
tested application :
Western Blot (WB)
app notes :
Western Blot:Use 1-5 ug/ml
other info1 :
Immunogen: Recombinant bovine SRY (RT #B30-001). Preparation: Produced from sera of rabbits pre-immunized with highly pure recombinant bovine SRY (Met1 - Tyr229) derived from E. coli.
other info2 :
Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. Buffer: PBS
products description :
The "žSex determining region of Y-Gen" (SRY), known as SRY gene, is coding for a transkription factor (TDF for Testis-determining factor). It belongs to the protein family of DNA binding-proteins. The SRY gene is beside other genes used for the determination of the sex in human as well as other mammals. Most mammals have for this purpose a further gene, UBE1. In humans SRY is normally located on the short arm of the Y chromosome. Accordingly, people who possess this chromosome with the corresponding gene, normally have a male phenotype. It does not matter how many copies of the X chromosome are present, even people with a multiple X chromosome (Klinefelter 's syndrome) have this. The protein encoded by the gene Testis-determining factor controls the development of male sex.
ncbi gi num :
62177084
ncbi acc num :
NP_001014407.1
ncbi gb acc num :
NM_001014385.1
uniprot acc num :
Q03255
ncbi mol weight :
26,627 Da
ncbi pathways :
Androgen Receptor Signaling Pathway (198553)
uniprot summary :
Function: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' . By similarity. Subunit structure: Interacts with CALM, EP300, HDAC3, KPNB1, KRAB-O/ZFP748, PARP1, SLC9A3R2 and WT1 . By similarity. Subcellular location: Nucleus speckle . By similarity. Cytoplasm . By similarity. Post-translational modification: Phosphorylation on serine residues enhances its DNA-binding activity and stimulates transcription repression. Acetylation of Lys-130 contributes to its nuclear localization and enhances its interaction with KPNB1. Deacetylated by HDAC3. Poly-ADP-ribosylation reduces its DNA-binding activity . By similarity. Sequence similarities: Belongs to the SRY family.Contains 1 HMG box DNA-binding domain.
size1 :
0.1 mg
price1 :
280 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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