Rabbit Anti-Human NRP-1 | MyBioSource MBS691201 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Anti-Human NRP-1

catalog :

MBS691201

quantity :

0.2 mg

price :

390 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS691201

products type :

Antibody

products full name :

Rabbit Anti-Human NRP-1

products short name :

NRP-1

products name syn :

Neuropilin receptor-1; VEGF165R; NRP; CD307; Neuropilin receptor-1; VEGF165R; NRP; CD304

other names :

neuropilin-1 isoform b; Neuropilin-1; neuropilin-1; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; neuropilin 1; Vascular endothelial cell growth factor 165 receptor

products gene name :

NRP-1

other gene names :

NRP1; NRP1; NP1; NRP; BDCA4; CD304; VEGF165R; NRP; VEGF165R

uniprot entry name :

NRP1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

sequence length :

644

purity :

Protein A purified

form :

Lyophilized

storage stability :

The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 degree C. Frozen aliquots are stable for at least 6 months when stored at -20 degree C.

tested application :

Western Blot (WB)

app notes :

Western Blot: Use at 1-5 ug/ml. ELISA: use at 1-5 ug/ml. IF/IHC: use at 1-5 ug/ml(IF on cells). FACS: use at 1-5 ug/ml

other info1 :

Antigen: Recombinant human NRP-1 (RT #S01-019)

other info2 :

Buffer: PBS. Reconstition: Centrifuge wial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml

ncbi gi num :

66912178

ncbi acc num :

NP_001019799.1

ncbi gb acc num :

NM_001024628.2

uniprot acc num :

O14786

ncbi mol weight :

103,134 Da

ncbi pathways :

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); CHL1 Interactions Pathway (161007); CRMPs In Sema3A Signaling Pathway (119525); Developmental Biology Pathway (477129); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); L1CAM Interactions Pathway (161003); Neurophilin Interactions With VEGF And VEGFR Pathway (106509)

ncbi summary :

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

uniprot summary :

Function: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform ofPGF, The VEGF-165 isoform ofVEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. Subunit structure: Homodimer, and heterodimer with NRP2. Interacts with FER . By similarity. Binds PLXNB1. Ref.10 Ref.16. Subcellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Tissue specificity: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Domain: The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding. Sequence similarities: Belongs to the neuropilin family.Contains 2 CUB domains.Contains 2 F5/8 type C domains.Contains 1 MAM domain.

size1 :

0.2 mg

price1 :

390 USD

more info or order :

MyBioSource product webpage