antibody

Mouse Anti-Human CCR6

MBS690913

0.1 mg

490 USD

monoclonal

mouse

nonconjugated

[(3L1)]

flow cytometry, FACS, immunohistochemistry - frozen section

Antibody

Mouse Anti-Human CCR6

[CCR6]

[CCR6; BN-1; DCR2; DRY6; CCR-6; CD196; CKRL3; GPR29; CKR-L3; CMKBR6; GPRCY4; STRL22; CC-CKR-6; C-C CKR-6]

[C-C chemokine receptor type 6; C-C chemokine receptor type 6; C-C chemokine receptor type 6; LARC receptor; chemokine receptor-like 3; chemokine (C-C) receptor 6; G protein-coupled receptor 29; G-protein coupled receptor 29; seven-transmembrane receptor, lymphocyte, 22; chemokine (C-C motif) receptor 6; Chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; GPR-CY4; GPRCY4; LARC receptor]

[CCR6]

[CCR6; CCR6; BN-1; DCR2; DRY6; CCR-6; CD196; CKRL3; GPR29; CKR-L3; CMKBR6; GPRCY4; STRL22; CC-CKR-6; C-C CKR-6; CKRL3; CMKBR6; GPR29; STRL22; C-C CKR-6; CC-CKR-6; CCR-6; CKR-L3; GPRCY4]

CCR6_HUMAN

Monoclonal

IgG2

[(3L1)]

Mouse

Human

Protein G chromatography

Lyophilized

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity. Avoid repeated freeze and thaw cycles.

Immunohistochemistry - Frozen (IHC-F), Flow Cytometry (FC/FACS)

FC: 1:100-1:800. IHC (Frozen): 1:50-1:200. Optimal dilutions should be determined by each laboratory for each application.

Immunohistochemistry (IHC)

Preparation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with 293 cells transfected with human CCR6. Antigen: Human CCR6 transfected 293 cells. Reconstitution Buffer: PBS (sterile)

Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. Note: This antibody was selected for its ability to detect human CCR6, not other CCRs.

CCR6 is a seven transmembrane-spanning G protein-coupled receptor that binds the chemokine MIP3alpha and mediates the chemoattraction of B and T lymphocytes.

37187860

NP_004358.2

NM_004367.5

P51684

Beta Defensins Pathway (530759); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defensins Pathway (530757); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548)

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Function: Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level. Ref.1. Subcellular location: Cell membrane; Multi-pass membrane protein. Tissue specificity: Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes. Induction: By IL2/interleukin-2. Sequence similarities: Belongs to the G-protein coupled receptor 1 family. Caution: It is uncertain whether Met-1 or Met-6 is the initiator. Sequence caution: The sequence CAB02144.1 differs from that shown. Reason: Erroneous initiation.

0.1 mg

490 USD