antibody

Mouse Anti-Human Galectin-4

MBS690870

0.1 mg

475 USD

monoclonal

mouse

nonconjugated

(1D12)

Antibody

Mouse Anti-Human Galectin-4

Galectin-4

LGALS3; L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2

galectin-4; Galectin-4; galectin-4; gal-4; galectin 4; antigen NY-CO-27; lactose-binding lectin 4; L-36 lactose-binding protein; lectin, galactoside-binding, soluble, 4; Antigen NY-CO-27; L-36 lactose-binding protein; L36LBP; Lactose-binding lectin 4

LGALS4; LGALS4; GAL4; L36LBP; Gal-4; L36LBP

LEG4_HUMAN

Monoclonal

IgG2

(1D12)

Mouse

Human

323

Protein G affinity chromatography

Lyophilized from a 0.2um filtered solution in phosphate-buffered saline (PBS).

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at Avoid repeated freeze-thaw cycles

Western Blot (WB)

Western Blot: Yes (1:500-1000). Optimal dilutions should be determined by each laboratory for each application.

Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Galectin-4. Antigen: Recombinant human Galectin-4

Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. Reconstituted antibody can also be aliquoted and stored frozen at <-20 degree C for at least six months without detectable loss of activity.

Galectin-4 is a member of the subfamily of galectins composed of two carbohydrate recognition domains having similar peptide chains. The galectins are a family of beta-galactoside-binding proteins having a role in modulating cell-cell and cell-matrix interactions, which inhibits chronic inflammations, GVHD, and allergic responses. LGALS4 expression is limited to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. LGALS4 binds as an endogenous ligand to glycosphingolipids having 3-O-sulfated Gal residues and bind as well to cholesterol-3-sulfate. LGALS4 takes part in cell adhesion. LGALS4 plays a role in crosslinking the lateral cell membranes of the surface-lining epithelial cells, thus supporting epithelial integrity against mechanical stress exerted by the bowel lume. The antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with the combinant human Galectin-4. The IgG 2 fraction of the tissue culture supernantant was purified by Protein G affinity chromatography.

5453712

NP_006140.1

NM_006149.3

P56470

35,941 Da

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]

Function: Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. Subunit structure: Monomer . By similarity. Domain: Contains two homologous but distinct carbohydrate-binding domains. Sequence similarities: Contains 2 galectin domains.

0.1 mg

475 USD