antibody

Rat Anti-Mouse TNFRSF18

MBS690710

0.1 mg

490 USD

monoclonal

rat

nonconjugated

[(7F34)]

western blot, neutralization

Antibody

Rat Anti-Mouse TNFRSF18

[TNFRSF18]

[Tnfrsf18; AITR; Gitr]

[tumor necrosis factor receptor superfamily member 18 isoform 1; Tumor necrosis factor receptor superfamily member 18; tumor necrosis factor receptor superfamily member 18; glucocorticoid-induced TNFR-related protein; tumor necrosis factor receptor superfamily, member 18; Glucocorticoid-induced TNFR-related protein]

[TNFRSF18]

[Tnfrsf18; Tnfrsf18; AITR; Gitr; Gitr]

TNR18_MOUSE

Monoclonal

IgG2

[(7F34)]

Rat

Mouse

228

This antibody detects specifically mouse TNFRSF18 with WB

Protein A/G chromatography

Lyophilized

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C . Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least for six months without detectable loss of activity. Shipping: Ships 4°C or RT

Western Blot (WB), Neutralization

WB: 2:250-1000. Neutralization: Yes

Antigen: Mouse recombinant protein TNFSF18. Preparation: This antibody was produced from hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant of TNFSF18.

Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. Reconstitution Buffer: PBS (sterile)

GITR (glucocorticoid-induced tumor necrosis factor receptor), also named AITR (activation-inducible TNFreceptor superfamily member) and TNFRSF18, is a 228amino acid typeI transmembrane protein belonging to the TNFreceptor superfamily. The GITR cytoplasmic domain has striking similarity to the cytoplasmic domain of 4-1BB and CD27.

6678383

NP_033426.1

NM_009400.2

O35714

25,334 Da

Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460)

Function: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway . By similarity. Subunit structure: Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 . By similarity. Binds through its C-terminus to SIVA1/SIVA. Ref.5. Subcellular location: Isoform A: Cell membrane; Single-pass type I membrane protein. Isoform B: Cell membrane; Single-pass type I membrane protein. Isoform C: Cell membrane; Single-pass type I membrane protein. Isoform D: Secreted. Tissue specificity: Preferentially expressed in activated T lymphocytes. Induction: Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation. Sequence similarities: Contains 3 TNFR-Cys repeats.

0.1 mg

490 USD