Mouse Anti-Human FGF-19 | MyBioSource MBS690654 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti-Human FGF-19

catalog :

MBS690654

quantity :

0.1 mg

price :

490 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[(4G16)]

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS690654

products type :

Antibody

products full name :

Mouse Anti-Human FGF-19

products short name :

[FGF-19]

products name syn :

[FGF19]

other names :

[fibroblast growth factor 19; Fibroblast growth factor 19; fibroblast growth factor 19; FGF-19; fibroblast growth factor 19]

products gene name :

[FGF-19]

other gene names :

[FGF19; FGF19; FGF-19]

uniprot entry name :

FGF19_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

[(4G16)]

host :

Mouse

reactivity :

Human

sequence length :

216

purity :

Protein G chromatography

form :

Lyophilized

storage stability :

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity. Avoid freeze-thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) - Paraffin

app notes :

WB: 1:500-1:1000, IHC-P: 1:20-1:100

other info1 :

Preparation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of fibroblast growth factor receptor 19. Antigen: Recombinant human FGF-18. Reconstitution Buffer: PBS (sterile). Remarks: This antibody was selected for its ability to detect human FGF-19.

other info2 :

Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. mRNA RefSeq: NM005117

products description :

Human FGF19 cDNA predicts a 251 aa precursor protein with a 22 aa signal peptide and a 229 aa secreted mature protein with no potential N-linked glycosylation sites. Among FGF family members, human FGF19 is most closely related to chicken FGF19 and murine FGF15, sharing approximately 61% and 51% aa sequence identity, respectively. Neither the human orthologue of mouse FGF15, nor the mouse counterpart of human FGF19 has been identified. With the exception of adult gall bladder epithelium, FGF19 expression is restricted to fetal tissues. Unlike most FGFs which bind to and activate more than one FGF receptor, FGF19 is a specific ligand for FGF R4. Similarly, another FGF family member, FGF7 (KGF), only activates KGF R, the IIIb isoform of FGF R2. During chick embryogenesis, FGF19 has been shown to act synergistically with Wnt8c to initiate inner ear development.

ncbi gi num :

4826726

ncbi acc num :

NP_005108.1

ncbi gb acc num :

NM_005117.2

uniprot acc num :

O95750

ncbi pathways :

Adaptive Immune System Pathway (366160); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (576250); Downstream Signal Transduction Pathway (106385); Downstream Signaling Of Activated FGFR Pathway (160957); FGF Signaling Pathway (137989); FGFR Ligand Binding And Activation Pathway (106344)

ncbi summary :

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. Ref.7 Ref.8 Ref.9 Ref.11. Subunit structure: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with KL; this interaction is direct. Interacts with KLB; this interaction is direct. Interacts with FGFR4 in the presence of heparin, KL or KLB. Ref.2 Ref.8 Ref.9 Ref.10 Ref.14. Subcellular location: Secreted. Tissue specificity: Expressed in fetal brain, cartilage, retina, and adult gall bladder. Ref.2. Induction: Induced by the bile acids receptor NR1H4 that binds and activates a NR1H4-responsive element within intron 2. Ref.7. Miscellaneous: Contrarily to other members of the family that can bind several FGF receptors FGF19 is specific for FGFR4. Sequence similarities: Belongs to the heparin-binding growth factors family.

size1 :

0.1 mg

price1 :

490 USD

more info or order :

MyBioSource product webpage