antibody

Rat Anti-Mouse IL-23 receptor

MBS690333

0.1 mg

475 USD

monoclonal

rat

nonconjugated

(6D34)

Antibody

Rat Anti-Mouse IL-23 receptor

IL-23 receptor

Anti-mouse Interleukin-23 Receptor (#6D34)

interleukin-23 receptor; Interleukin-23 receptor; interleukin-23 receptor; IL-23 receptor; interleukin 23 receptor

IL-23 receptor

Il23r; Il23r; IL-23R; IL-23 receptor; IL-23R

IL23R_MOUSE

Monoclonal

IgG2

(6D34)

Rat

Mouse

659

This antibody detects mouse IL-23R in Western blotting.

Protein A/G affinity chromatography

Lyophilized

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Western Blot (WB)

1. Western blot: Yes (1:500-1000)

Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant protein of IL-23R extracellular domain. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography. Antigen: Mouse recombinant EC domain of IL-23 R

Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 R shares structural features with the IL-12 R beta 2, including an N-terminal Ig-like domain, two cytokine receptor domains and multiple glycosylation sites in the extracellular domain. IL-23 R lacks the three extracellular membrane-proximal fibronectin-type III domains present on IL-12 R beta 2.

239052137

NP_653131.2

NM_144548.1

Q8K4B4

73,453 Da

Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); Inflammatory Bowel Disease (IBD) Pathway (842778); Inflammatory Bowel Disease (IBD) Pathway (842797); Jak-STAT Signaling Pathway (83274); Jak-STAT Signaling Pathway (488)

Function: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis . By similarity. Subunit structure: Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3 . By similarity. Subcellular location: Cell membrane; Single-pass type I membrane protein . By similarity. Tissue specificity: Expressed by Th1, Th2 and dendritic cells. Ref.1. Post-translational modification: Phosphorylated in response to IL23 . By similarity. Sequence similarities: Belongs to the type I cytokine receptor family. Type 2 subfamily.Contains 2 fibronectin type-III domains.

0.1 mg

475 USD