Mouse Anti-Human IL-22 BP | MyBioSource MBS690164 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti-Human IL-22 BP

catalog :

MBS690164

quantity :

0.1 mg

price :

490 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[(6G42)]

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS690164

products type :

Antibody

products full name :

Mouse Anti-Human IL-22 BP

products short name :

[IL-22 BP]

products name syn :

[IL22RA2; CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2]

other names :

[interleukin-22 receptor subunit alpha-2 isoform 1; Interleukin-22 receptor subunit alpha-2; interleukin-22 receptor subunit alpha-2; interleukin 22-binding protein; cytokine receptor class-II member 10; cytokine receptor family type 2, soluble 1; interleukin 22 receptor, alpha 2; Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; CRF2-10; Cytokine receptor family type 2, soluble 1; CRF2-S1; Interleukin-22-binding protein; IL-22BP; IL22BP; ZcytoR16]

products gene name :

[IL-22 BP]

other gene names :

[IL22RA2; IL22RA2; CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2; IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; CRF2-10; CRF2-S1; IL-22BP; IL22BP]

uniprot entry name :

I22R2_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

[(6G42)]

host :

Mouse

reactivity :

Human

sequence length :

263

purity :

Protein G chromatography

form :

Lyophilized

storage stability :

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least for six months without detectable loss of activity.

tested application :

Western Blot (WB)

app notes :

Western Blot: 1:500-1:2000

other info1 :

Preparation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of IL-22BP. Antigen: Recombinant human IL-22BP. Reconstitution buffer: PBS (sterile)

other info2 :

Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. Remarks: This antibody was selected for its ability to detect IL22BP.

products description :

Interleukin 22 binding protein (IL-22BP), also known as cytokine receptor family (CRF) 2-10, CRF2-X, and IL-22 RA2, is a secreted glycoprotein belonging to the type II cytokine receptor family. IL-22BP antagonizes IL-22 activity by specifically binding IL-22 with high affinity and blocking its interaction with the cell surface IL-22 receptor heteromeric complex composed of IL-22R and IL-10R2 (IL-10 R beta). The highest levels of IL-22BP expression are found in breast, lungs and colon.

ncbi gi num :

16418459

ncbi acc num :

NP_443194.1

ncbi gb acc num :

NM_052962.2

uniprot acc num :

Q969J5

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488)

ncbi summary :

This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

uniprot summary :

Function: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Ref.2 Ref.3 Ref.4Isoform 1 may play a role in establishing and maintaining successful pregnancy. Ref.2 Ref.3 Ref.4. Subcellular location: Secreted Ref.12. Tissue specificity: Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach. Ref.1 Ref.4 Ref.11. Sequence similarities: Belongs to the type II cytokine receptor family.Contains 3 fibronectin type-III domains. Sequence caution: The sequence AAQ89097.1 differs from that shown. Reason: Erroneous initiation.

size1 :

0.1 mg

price1 :

490 USD

more info or order :

MyBioSource product webpage