Anti-Human BAFF | MyBioSource MBS690156 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Human BAFF

catalog :

MBS690156

quantity :

0.5 mg

price :

440 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS690156

products type :

Antibody

products full name :

Anti-Human BAFF

products short name :

[BAFF]

products name syn :

[Monoclonal antibody anti-human BAFF]

other names :

[type 2 lactosamine alpha-2,3-sialyltransferase isoform 3; Type 2 lactosamine alpha-2,3-sialyltransferase; type 2 lactosamine alpha-2,3-sialyltransferase; alpha2,3-sialyltransferase ST3Gal VI; sialyltransferase 10 (alpha-2,3-sialyltransferase VI); CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI; ST3 beta-galactoside alpha-2,3-sialyltransferase 6; CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI; ST3Gal VI; ST3GalVI; Sialyltransferase 10]

products gene name :

[BAFF]

other gene names :

[ST3GAL6; ST3GAL6; SIAT10; ST3GALVI; SIAT10; ST3GalVI]

uniprot entry name :

SIA10_HUMAN

clonality :

Monoclonal

isotype :

IgG1, kappa

host :

Mouse

reactivity :

Human

sequence length :

384

purity :

Protein G chromatography

form :

Lyophilized

storage stability :

Stability: Lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least 2 weeks at 2-8 degree C. Frozen aliquots are stable for at least 6 months when stored at -20 degree C.

tested application :

ELISA; Western Blot (WB)

app notes :

ELISA: . In a Sandwich ELISA (assuming 100 ?l/well), a concentration of 5-6 ug/ml of this antibody will detect at least 1000 pg/ml of recombinant Human BAFF when used in conjunction with an appropriate conjugated secondary antibody as detection system. Western Blot:. To detect hBAFF by Western Blot analysis this antibody can be used at a concentration of 0.25 - 0.50 ug/ml. When used in conjunction with compatible secondary reagents the detection limit for recombinant hBAFF is 1 - 2 ng/lane, under reducing and non-reducing conditions.

other info1 :

Immunogen: highly pure (>98%) recombinant human BAFF. Antibody Generation: Monoclonal antibodies were produced in BALB/c mice using recombinant human BAFF as the immunizing antigen. This IgG1/K antibody was purified from ascites fluid on a protein A chromatography column. Protein RefSeq: NP_006564.1. Uniprot ID: Q9Y274. mRNA RefSeq: NM_006573.4

other info2 :

Buffer: PBS. Reconstitution buffer: water. Reconstitution: Centrifuge vial prior to opening. Reconstitute the antibody in sterile water to a concentration of 0.1 - 1.0 mg/ml.

products description :

BAFF, also known as Blymphocyte stimulator (BLyS), TNFand APO-Lrelated leukocyte expressed ligand 1 (TALL1), and TNF homolog that activates apoptosis, NFKB and JNK (THANK), is a TNF ligand superfamily member and has been designated TNFSF13B.

ncbi gi num :

403225032

ncbi acc num :

NP_001258074.1

ncbi gb acc num :

NM_001271145.1

uniprot acc num :

Q9Y274

ncbi mol weight :

38,214 Da

ncbi pathways :

Disease Pathway (530764); Glycosaminoglycan Metabolism Pathway (645297); Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway (82995); Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway (370); Keratan Sulfate Biosynthesis Pathway (645302); Keratan Sulfate/keratin Metabolism Pathway (645301); MPS I - Hurler Syndrome Pathway (685537); MPS II - Hunter Syndrome Pathway (685538); MPS IIIA - Sanfilippo Syndrome A Pathway (685539); MPS IIIB - Sanfilippo Syndrome B Pathway (685540)

ncbi summary :

The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012]

uniprot summary :

Function: Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1. Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein . Potential. Tissue specificity: Ubiquitous. Sequence similarities: Belongs to the glycosyltransferase 29 family.

size1 :

0.5 mg

price1 :

440 USD

more info or order :

MyBioSource product webpage