Mouse Anti-Human Common gamma chain | MyBioSource MBS690148 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti-Human Common gamma chain

catalog :

MBS690148

quantity :

0.1 mg

price :

475 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

(7A23)

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS690148

products type :

Antibody

products full name :

Mouse Anti-Human Common gamma chain

products short name :

Common gamma chain

products name syn :

Common gamma chain

other names :

cytokine receptor common subunit gamma; Cytokine receptor common subunit gamma; cytokine receptor common subunit gamma; gammaC; CD132 antigen; IL-2R subunit gamma; IL-2 receptor subunit gamma; common cytokine receptor gamma chain; interleukin 2 receptor, gamma; Interleukin-2 receptor subunit gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; gammaC; p64

other gene names :

IL2RG; IL2RG; P64; CIDX; IMD4; CD132; SCIDX; IL-2RG; SCIDX1; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG

uniprot entry name :

IL2RG_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

(7A23)

host :

Mouse

reactivity :

Human

sequence length :

369

specificity :

This antibody was selected for its ability to detect human Common gamma chain.

purity :

Protein G affinity chromatography

form :

Lyophilized from a 0.2um filtered solution in phosphate-buffered saline (PBS)

storage stability :

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

tested application :

Western Blot (WB), Neutr

app notes :

WB: Yes at 1:500-1000; Neutralization of Gamma Chian of mediated signaling: Yes

other info1 :

Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Common g chain. The IgG1 fraction of culture supernatant was purified by Protein G affinity chromatography. Antigen: Recombinant human Common gamma chain.

other info2 :

Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. Reconstituted antibody can also be aliquoted and stored frozen at <-20 degree C for at least 6 months without detectable loss of activity. Stabilizer: None

products description :

When IL-2 R alpha is associated with the IL-2 receptor beta and gamma chains, a high affinity heterotrimeric receptor complex that transduces IL-2 signals is formed. The gamma chain is also the common signaling subunit of the high affinity receptor complex for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21.

ncbi gi num :

4557882

ncbi acc num :

NP_000197.1

ncbi gb acc num :

NM_000206.2

uniprot acc num :

P31785

ncbi mol weight :

42,287 Da

ncbi pathways :

Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); Endocytosis Pathway (102279); Endocytosis Pathway (102181); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); IL-2 Signaling Pathway (198885); IL-4 Signaling Pathway (198760)

ncbi summary :

The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]

uniprot summary :

Function: Common subunit for the receptors for a variety of interleukins. Subunit structure: The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 and probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I. Ref.8 Ref.9 Ref.10 Ref.11 Ref.12. Subcellular location: Membrane; Single-pass type I membrane protein. Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation. Involvement in disease: Severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID) [MIM:300400]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.3 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.25 Ref.26 Ref.27X-linked combined immunodeficiency (XCID) [MIM:312863]: Less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.24 Ref.28. Sequence similarities: Belongs to the type I cytokine receptor family. Type 5 subfamily.Contains 1 fibronectin type-III domain.

size1 :

0.1 mg

price1 :

475 USD

more info or order :

MyBioSource product webpage