Mouse Anti-Human TNFSF4 | MyBioSource MBS690102 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti-Human TNFSF4

catalog :

MBS690102

quantity :

0.1 mg

price :

490 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[(8S23)]

reactivity :

human

application :

immunohistochemistry, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS690102

products type :

Antibody

products full name :

Mouse Anti-Human TNFSF4

products short name :

[TNFSF4]

products name syn :

[TNFSF4; GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; Ox 40 Ligand]

other names :

[tumor necrosis factor ligand superfamily member 4; Tumor necrosis factor ligand superfamily member 4; tumor necrosis factor ligand superfamily member 4; OX40L; CD134 ligand; glycoprotein Gp34; OX40 antigen ligand; TAX transcriptionally-activated glycoprotein 1; tax-transcriptionally activated glycoprotein 1 (34kD); tumor necrosis factor (ligand) superfamily, member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1]

products gene name :

[TNFSF4]

other gene names :

[TNFSF4; TNFSF4; GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; TXGP1; OX40L]

uniprot entry name :

TNFL4_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

[(8S23)]

host :

Mouse

reactivity :

Human

sequence length :

183

specificity :

This antibody was selected for its ability to detect human TNFS4

purity :

Protein G Chromatography

form :

Lyophilized

storage stability :

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. Shipping: Ships 4°C or RT

tested application :

Immunohistochemistry (IHC) - Formalin, Flow Cytometry (FC/FACS), Neutr

app notes :

FC: 1:50-100. IHC (Frozen): 1:20-200. optimal dilutions shoudl be determined by each laboratory for each application

other info1 :

Preparation: This antibody war produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human TNFSF4, also called Ox40 ligand. The IgG fraction of culture supernatant was purified by Protein G affinity chromatography. Immunogen: Recombiant human TNFSF4

other info2 :

Reconstitution Buffer: PBS (sterile). Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

products description :

OX40 Ligand (OX40L), also known as gp34, is a member of the TNF superfamily. Human OX40L shares 46% amino acid sequence identity with its mouse counterpart. OX40L is expressed on the surface of activated B cells, T cells, dendritic cells and endothelial cells. Similar to other TNF superfamily members, membrane-bound OX40 Ligand exists as a homotrimer. OX40L binds to OX40 (CD134), a member of the TNF receptor superfamily, which is expressed predominantly on activated CD4+ T cells.

ncbi gi num :

4507603

ncbi acc num :

NP_003317.1

ncbi gb acc num :

NM_003326.3

uniprot acc num :

P23510

ncbi mol weight :

21,050 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); TSLP Signaling Pathway (672451)

ncbi summary :

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Subunit structure: Homotrimer. Ref.8. Subcellular location: Membrane; Single-pass type II membrane protein. Induction: By HTLV-1 transactivator p40-Tax. Involvement in disease: Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance. Ref.7. Sequence similarities: Belongs to the tumor necrosis factor family. Sequence caution: The sequence CAA18438.2 differs from that shown. Reason: Erroneous gene model prediction.

size1 :

0.1 mg

price1 :

490 USD

more info or order :

MyBioSource product webpage