Mouse Anti-Human CTGF | MyBioSource MBS690096 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti-Human CTGF

catalog :

MBS690096

quantity :

0.1 mg

price :

490 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[(6B13)]

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS690096

products type :

Antibody

products full name :

Mouse Anti-Human CTGF

products short name :

[CTGF]

products name syn :

[Anti human CTGF (#6B13)]

other names :

[connective tissue growth factor; Connective tissue growth factor; connective tissue growth factor; IBP-8; IGFBP-8; CCN family member 2; IGF-binding protein 8; hypertrophic chondrocyte-specific protein 24; insulin-like growth factor-binding protein 8; connective tissue growth factor; CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8]

products gene name :

[CTGF]

other gene names :

[CTGF; CTGF; CCN2; NOV2; HCS24; IGFBP8; CCN2; HCS24; IGFBP8; IBP-8; IGF-binding protein 8; IGFBP-8]

uniprot entry name :

CTGF_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

[(6B13)]

host :

Mouse

reactivity :

Human

sequence length :

349

specificity :

This antibody recognizes human CTGF with Elisa and immunohistochemistry.

purity :

Protein G chromatography

form :

Lyophilized

storage stability :

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity. Ships on cold packs

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

app notes :

1. Immunohistochemistry (Paraffin): Yes (1:50-200) 2. Elisa: Yes

image1 heading :

Immunohistochemistry

other info1 :

Synonyms (TARGET): CTGF; CCN2; NOV2; HCS24; IGFBP8. Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with recombinant human Connective Tissue Growth Factor (CTGF). The IgG1 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography. Antigen: Human recombinant CTGF

other info2 :

Reconstitution buffer: PBS (Sterile). Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

products description :

CTGF belongs to the CCN (CYR61/CTGF/NOV) family of secreted proteins that share a common multimodular organization. Each protein contains an IGF-binding protein domain, a von Willebrand factor type C domain, a thrombospondin type I domain, and a cysteine knot domain. The multimodular CTGF has the ability to bind multiple ligands and has numerous effects on development, differentation, and disease. The C-terminal cysteine knot motif contains the heparin and low density lipoprotein receptor (LDLR) binding sites that contribute to the adhesive and mitogenic properties of CTGF.

ncbi gi num :

4503123

ncbi acc num :

NP_001892.1

ncbi gb acc num :

NM_001901.2

uniprot acc num :

P29279

ncbi pathways :

Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); PPARA Activates Gene Expression Pathway (530749); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (119544); TGF-beta Receptor Signaling Pathway (138024)

ncbi summary :

The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]

uniprot summary :

Function: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Ref.14 Ref.15. Subunit structure: Monomer. Subcellular location: Secreted extracellular space extracellular matrix . By similarity. Secreted . By similarity. Tissue specificity: Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. Ref.13. Sequence similarities: Belongs to the CCN family.Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 1 IGFBP N-terminal domain.Contains 1 TSP type-1 domain.Contains 1 VWFC domain.

size1 :

0.1 mg

price1 :

490 USD

more info or order :

MyBioSource product webpage