Mouse Anti-Human IL-1F7 | MyBioSource MBS690079 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti-Human IL-1F7

catalog :

MBS690079

quantity :

0.1 mg

price :

475 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

(4C33)

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS690079

products type :

Antibody

products full name :

Mouse Anti-Human IL-1F7

products short name :

IL-1F7

products name syn :

IL37; FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)

other names :

interleukin-37 isoform 1; Interleukin-37; interleukin-37; FIL1 zeta; IL-1 zeta; IL-1X protein; interleukin-23; interleukin 1, zeta; interleukin-1 homolog 4; interleukin-1 superfamily z; interleukin 1 family member 7; interleukin-1-related protein; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL1F7 (canonical product IL-1F7b); interleukin 37; FIL1 zeta; IL-1X; Interleukin-1 family member 7; IL-1F7; Interleukin-1 homolog 4; IL-1H; IL-1H4; Interleukin-1 zeta; IL-1 zeta; Interleukin-1-related protein; IL-1RP1; Interleukin-23

products gene name :

IL-1F7

other gene names :

IL37; IL37; FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA); FIL1Z; IL1F7; IL1H4; IL1RP1; IL-1F7; IL-1H; IL-1H4; IL-1 zeta; IL-1RP1; IL-37

uniprot entry name :

IL37_HUMAN

clonality :

Monoclonal

isotype :

IgG2

clone :

(4C33)

host :

Mouse

reactivity :

Human

sequence length :

218

specificity :

This antibody was selected for its ability to detect human Il-1F7.

purity :

Protein G chromatography

form :

Lyophilized from a 0.2um filtered solution in phosphate-buffered saline (PBS).

storage stability :

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

tested application :

Western Blot (WB), Neutralization of IL-13 Bioactiviy. Optimal dilutions should be determined by each laboratory for each application.

other info1 :

Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of IL-1F7.

other info2 :

Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. Reconstituted antibody can also be aliquoted and stored frozen at Avoid repeated freeze-thaw cycles. . Antigen: Recombinant protein of IL-1F7. Stabilizer: None. Buffer: PBS

products description :

This antibody was produced from a hybridoma (mouse myeloma fused with speen cells from a mouse) immunized with human recombinant protein of IL-1F7. This IgG2 antibody was purified from cell culture by Protein G affinity chomatography.

ncbi gi num :

20127524

ncbi acc num :

NP_055254.2

ncbi gb acc num :

NM_014439.3

uniprot acc num :

Q9NZH6

ncbi mol weight :

24,126 Da

ncbi summary :

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. Ref.11 Ref.12. Subunit structure: Interacts with SMAD3. Binds IL18R1, but not to IL1R1, with lower affinity than IL18, and does not seem to act as a receptor antagonist for IL18. Ref.3 Ref.12. Subcellular location: Cytoplasm cytosol. Nucleus. Secreted. Note: Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation. Ref.3 Ref.11 Ref.12. Tissue specificity: In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart. Ref.3 Ref.12. Induction: Highly induced by bacterial lipopolysaccharides (LPS) and TGFB1, more moderately by IFNG, IL18, IL1B, TNF and the dinucleotide CpG (at protein level). Constitutive expression in bone marrow macrophages is down-regulated in the presence of IL4 and CSF2. Induced by phorbol myristate acetate (PMA) in different cell lines. Ref.11 Ref.12. Post-translational modification: Proteolytically converted to the mature form by CASP1. Sequence similarities: Belongs to the IL-1 family.

size1 :

0.1 mg

price1 :

475 USD

more info or order :

MyBioSource product webpage