antibody

Rat Anti-Mouse IL-1 R1

MBS690058

0.1 mg

475 USD

monoclonal

rat

nonconjugated

(11B7)

Antibody

Rat Anti-Mouse IL-1 R1

IL-1 R1

Il1r1; IL-iR; CD121a; CD121b; Il1r-1; Interleukin 1 receptor 1

interleukin-1 receptor type 1 isoform 1; Interleukin-1 receptor type 1; interleukin-1 receptor type 1; p80; IL-1R-1; IL-1RT1; IL-1RT-1; IL-1R-alpha; IL-1 receptor alpha chain; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family member A; interleukin 1 receptor, type I; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80

IL-1 R1

Il1r1; Il1r1; IL-iR; CD121a; CD121b; Il1r-1; Il-1r1; Il1ra; IL-1R-1; IL-1RT-1; IL-1RT1; IL-1R-alpha; mIL-1R1; mIL-1RI; sIL-1R1; sIL-1RI

IL1R1_MOUSE

Monoclonal

IgG2

(11B7)

Rat

Mouse

576

Prot ein G/A chromatography

Lyophilized

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity. Shipping: Ships on cold packs.

Western Blot (WB)

Western blot: (1:500-1:1000)

Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant extracellular domain of mouse IL-1 R1 protein. IgG2 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography. Antigen: ext racellular domain of mouse IL1R - I

Reconstitution: buffer PBS (sterile). Remarks: This antibody was selected for its ability to detect mouse IL-1 R1.

IL-1 receptor type I (IL1R-I) is an 80 kD transmembrane glycoprotein and a member of the immunoglobulin superfamily expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. IL1R-I binds the mature forms of IL-1alpha, IL-1beta, and IL-1Ra proteins. High affinity binding and signaling by the type I IL-1 receptor requires CD121a and the accessory protein, IL-1R AcP, which does not bind IL-1 alone, but forms a dimer capable of binding IL-1.

6680417

NP_032388.1

NM_008362.2

P13504

Amoebiasis Pathway (167330); Amoebiasis Pathway (167191); Apoptosis Pathway (83257); Apoptosis Pathway (470); Apoptosis Signaling Pathway (522973); Cytokine Signaling In Immune System Pathway (926145); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); HTLV-I Infection Pathway (373903); HTLV-I Infection Pathway (373889)

Function: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex . By similarity. Subunit structure: The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1 . By similarity. Ref.3 Ref.4. Subcellular location: Membrane; Single-pass type I membrane protein. Cell membrane . Probable. Secreted . By similarity. Post-translational modification: A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding) . By similarity.Rapidely phosphorylated on Tyr-499 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1 . By similarity. Ref.2. Sequence similarities: Belongs to the interleukin-1 receptor family.Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 TIR domain.

0.1 mg

475 USD