catalog number :
MBS690039
products full name :
Mouse Anti-Human CD200
products short name :
CD200
products name syn :
CD200; MRC; MOX1; MOX2; OX-2
other names :
OX-2 membrane glycoprotein isoform b; OX-2 membrane glycoprotein; OX-2 membrane glycoprotein; CD200 antigen; MRC OX-2 antigen; antigen identified by monoclonal antibody MRC OX-2; CD200 molecule
products gene name :
CD200
other gene names :
CD200; CD200; MRC; MOX1; MOX2; OX-2; MOX1; MOX2
uniprot entry name :
OX2G_HUMAN
purity :
Protein G chromatography
storage stability :
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
tested application :
Neutr
other info1 :
Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of CD200.
other info2 :
Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
products description :
CD200 antigen, also known as OX-2, is a type I transmembrane protein belonging to the Ig superfamily. It has a 202 amino acid extracellular domain and a short (19 aa) cytoplasmic tail. At least two alternate splice isoforms exist that differ in their cytoplasmic domains. CD200 is widely expressed in multiple cell types. It interacts with CD200 R1, another Ig superfamily inhibitory receptor primarily expressed on leukocytes of the myeloid lineage, to inhibit myeloid functions.
ncbi acc num :
NP_001004196.2
ncbi gb acc num :
NM_001004196.2
ncbi mol weight :
31,264 Da
ncbi pathways :
Adaptive Immune System Pathway (366160); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413)
ncbi summary :
The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. Subunit structure: Interacts with CD200R1. Subcellular location: Cell membrane; Single-pass type I membrane protein. Sequence similarities: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain.