antibody

Rat Anti-Mouse IL-16

MBS690015

0.1 mg

490 USD

monoclonal

rat

nonconjugated

[(3G41)]

Antibody

Rat Anti-Mouse IL-16

[IL-16]

[Il16; mKIAA4048]

[pro-interleukin-16; Pro-interleukin-16; pro-interleukin-16; interleukin 16; Lymphocyte chemoattractant factor]

[IL-16]

[Il16; Il16; mKIAA4048; IL-16; LCF]

IL16_MOUSE

Monoclonal

IgG2

[(3G41)]

Rat

Mouse

1322

This antibody detects specifically mouse IL-17 with WB

Protein A/G chromatography

Lyophilized

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least for six months without detectable loss of activity. Avoid repeated freeze and thaw cycles. Shipping: Ships in blue ice at 4°C.

Western Blot (WB)

WB: 1:50-200

Preparation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of IL-16. Antigen: Mouse recombinant protein of IL-16

Reconstitution Buffer: PBS (sterile). Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

Interleukin 16 (IL-16), also named lymphocyte chemoattractant factor (LCF), is a 14-17 kDa single chain non-glycosylated polypeptide that was originally identified as a CD8+ T cell-derived chemoattractant for CD4+ cells. The expression of IL-16 precursor mRNA has been detected in various tissues including spleen, thymus, lymph nodes, peripheral leukocytes, bone marrow and cerebellum. In addition to its chemotactic properties, IL-16 has also been shown to suppress HIV-1 replication in vitro.

52138550

NP_034681.2

NM_010551.3

O54824

Function: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. Subunit structure: Homotetramer . Probable. Isoform 2 interacts with GRIN2A. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C. Isoform 2 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3interacts with GABPB1. Isoform 2 interacts (via PDZ 3 domain) with HDAC3 . By similarity. Ref.3. Subcellular location: Secreted . By similarity Ref.3. Isoform 1: Cytoplasm. Note: Colocalizes with GRIN2C in neuronal cell bodies and neurites. Ref.3Isoform 2: Cytoplasm. Nucleus . By similarity Ref.3. Tissue specificity: Isoform 1 is expressed in neurons of the cerebellum and hippocampus. Isoform 2 is expressed in thymus, spleen and lung. Ref.1 Ref.3. Post-translational modification: Synthesized as a chemo-attractant inactive precursor which is proteolytically cleaved by caspase-3 to yield IL-16. Ref.3. Sequence similarities: Contains 4 PDZ (DHR) domains.

0.1 mg

490 USD