Goat anti-Factor B - Affinity Pure | MyBioSource MBS686026 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Factor B - Affinity Pure

catalog :

MBS686026

quantity :

1 mg

price :

240 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, cow

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS686026

products type :

Antibody

products full name :

Goat anti-Factor B - Affinity Pure

products short name :

[Factor B]

other names :

[factor B; Complement factor B; complement factor B; complement factor B; C3/C5 convertase; Glycine-rich beta glycoprotein; GBG]

other gene names :

[CFB; CFB; BF; FB; BFD; GBG; CFAB; CFBD; PBF2; AHUS4; FBI12; H2-Bf; ARMD14; BF; BFD; GBG]

clonality :

polyclonal

host :

goat

reactivity :

Factor B

sequence length :

621

specificity :

Human Factor B (C3 Proactivator)

purity :

> 95% based on SDS-PAGE. Affinity purified using solid phase Human Factor B (C3 Proactivator).

form :

Clear, colorless liquid, 0.2 um filtered

concentration :

> 4.5 mg/ml (E 1% at 280 nm = 13.0)

storage stability :

Store at 2-8 degree C

tested application :

Western Blot (WB), ELISA (EIA)

other info1 :

Conjugate: UnConjugated. Immunogen: Human Factor B (C3 Proactivator). Buffer: 10 mM Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2

other info2 :

Preservative: 0.05% (w/v) Sodium Azide. Country of Origin: Goat serum was obtained from healthy animals of US origin and under the care of a registered veterinarian.

products categories :

Primary Antibodies

ncbi gi num :

13560705

ncbi acc num :

AAK30167

ncbi mol weight :

68,872 Da

ncbi pathways :

Activation Of C3 And C5 Pathway (106412); Alternative Complement Activation Pathway (106410); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Immune System Pathway (106386); Initial Triggering Of Complement Pathway (106406); Innate Immune System Pathway (106387); Regulation Of Complement Cascade Pathway (576254); Staphylococcus Aureus Infection Pathway (172846)

ncbi summary :

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]

uniprot summary :

CFB: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.21.47; Protease; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 6p21.33. Cellular Component: extracellular region; extracellular space; plasma membrane. Molecular Function: complement binding; serine-type endopeptidase activity. Biological Process: complement activation; complement activation, alternative pathway; regulation of complement activation. Disease: Complement Factor B Deficiency; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 4; Macular Degeneration, Age-related, 14

size1 :

1 mg

price1 :

240 USD

more info or order :

MyBioSource product webpage