antibody

Anti-Nephrin FITC

MBS684285

0.1 mL

210 USD

polyclonal

rabbit

FITC

[D13-E]

Antibody

Anti-Nephrin FITC

[Nephrin]

[Anti-nephrin]

[nephrin; Nephrin; nephrin; NPHS1 nephrin; Renal glomerulus-specific cell adhesion receptor]

[NPHS1; NPHS1; CNF; NPHN; nephrin; NPHN]

NPHN_HUMAN

polyclonal

IgG

[D13-E]

rabbit

Human

1241

Aqueous buffer solution containing 10mg/ml of BSA and 0.05% sodium azide.

Store undiluted at 4°C, protect from prolonged exposure to light. Do not freeze.

Flow Cytometry (FC/FACS)

Preparation: The antibody was prepared by in vitro cloning technology, and the monospecific product was conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC and unconjugated antibody.

Important Notes: This antibody detects intracellular antigen (cells of interest must be permeabilized). Optimal dilution should be determined by the end user. Use 1×10 6 cells in a 100 ul experimental sample (a test). This product is for in vitro use only, research or diagnostic applications. Caution: Product contains sodium azide.

FITC Rabbit Anti-Human Nephrin

10441644

AAG17141.1

Cell-Cell Communication Pathway (1270231); Nephrin Interactions Pathway (1270243); Nephrin/Neph1 Signaling In The Kidney Podocyte Pathway (138072)

This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009]

NPHS1: Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion. Interacts with CD2AP (via C-terminal domain). Interacts with MAGI1 (via PDZ 2 and 3 domains) forming a tripartite complex with IGSF5/JAM4. Interacts with DDN; the interaction is direct. Self-associates (via the Ig-like domains). Also interacts (via the Ig-like domains) with KIRREL/NEPH1 and KIRREL2; the interaction with KIRREL is dependent on KIRREL glycosylation. Forms a complex with ACTN4, CASK, IQGAP1, MAGI2, SPTAN1 and SPTBN1. Interacts with NPHS2. Specifically expressed in podocytes of kidney glomeruli. Belongs to the immunoglobulin superfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Immunoglobulin superfamily; Cell adhesion. Chromosomal Location of Human Ortholog: 19q13.1. Cellular Component: cell projection; integral to plasma membrane; intracellular; plasma membrane. Molecular Function: myosin binding; protein binding. Biological Process: cell adhesion; excretion; glomerular basement membrane development; JNK cascade; myoblast fusion; positive regulation of actin filament polymerization; skeletal muscle development. Disease: Nephrotic Syndrome, Type 1

0.1 mL

210 USD

100 Tests

915