antibody

Anti - TRYPSIN

MBS684122

0.1 ml Concentrate

530 USD

monoclonal

rabbit

nonconjugated

A16-N

western blot, ELISA, immunoprecipitation, enzyme immunoassay

Antibody

Anti - TRYPSIN

TRYPSIN

Trypsin-1; Trypsin-1; trypsin-1; beta-trypsin; trypsinogen 1; trypsinogen A; digestive zymogen; cationic trypsinogen; nonfunctional trypsin 1; protease, serine, 1 (trypsin 1); Beta-trypsin; Cationic trypsinogen; Serine protease 1; Trypsin I

TRYPSIN

PRSS1; PRSS1; TRP1; TRY1; TRY4; TRYP1; TRP1; TRY1; TRYP1

TRY1_HUMAN

Monoclonal

A16-N

Rabbit

Human

247

Human

Store at -20 degree C

ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)

WB - 1:4 000, ELISA - 1:20 000 - 1:50 000

Immunogen: Peptide derived from near the N terminus of human pancreatic cationic trypsin. Storage Buffer: 20 mM Tris-HCI, pH 8.0. Stabilizer: 10 mg/ml BSA

Preservative: 0.05% NaN3. Regulatory Status: ISO 9001:2008, ISO 13485:2003, CE

136408

P07477.1

P07477

26,558 Da

Activation Of Matrix Metalloproteinases Pathway 576264!!Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway 833804!!Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway 906000!!Defective BTD Causes Biotidinase Deficiency Pathway 906015!!Defective CD320 Causes Methylmalonic Aciduria Pathway 906012!!Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway 906001!!Defective GIF Causes Intrinsic Factor Deficiency Pathway 906004!!Defective HLCS Causes Multiple Carboxylase Deficiency Pathway 906014!!Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway 906003!!Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway 906010

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]

Function: Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates. Ref.9. Catalytic activity: Preferential cleavage: Arg- -Xaa, Lys- -Xaa. Cofactor: Binds 1 calcium ion per subunit. Subcellular location: Secreted extracellular space. Post-translational modification: Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122. Involvement in disease: Pancreatitis (PCTT) [MIM:167800]: A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8 Ref.11 Ref.12 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23. Sequence similarities: Belongs to the peptidase S1 family.Contains 1 peptidase S1 domain. Caution: Tyr-154 was proposed to be phosphorylated (Ref.15) but it has been shown (Ref.14) to be sulfated instead. Phosphate and sulfate groups are similar in mass and size, and this can lead to erroneous interpretation of the results. Mass spectrometry: Molecular mass is 24348 2 Da from positions 24 - 247. Determined by ESI. Ref.15

0.1 ml Concentrate

530 USD