antibody

Anti - CD 20

MBS684044

7 ml

345 USD

monoclonal

rabbit

nonconjugated

E17-P

immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Anti - CD 20

CD 20

B-lymphocyte antigen CD20; B-lymphocyte antigen CD20; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1; membrane-spanning 4-domains, subfamily A, member 1; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1

CD 20

MS4A1; MS4A1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; CD20

CD20_HUMAN

Monoclonal

E17-P

Rabbit

Human

297

Human

Store at +4 degree C.

Immunohistochemistry (IHC) - Formalin/Paraffin

IHC-P dilution 1:100 - 1:200; IHC-Fr application and dilution to be tested by the user

Immunogen: Peptide derived from C-terminal sequence of human CD 20. Storage Buffer: 20 mM Tris-HCI, pH 8.0. Stabilizer: 20 mg/ml BSA

Preservative: 0.05% NaN3. Regulatory Status: ISO 9001:2008, ISO 13485:2003, CE

115968

P11836.1

P11836

33,077 Da

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]

Function: This protein may be involved in the regulation of B-cell activation and proliferation. Subcellular location: Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor Ref.11. Tissue specificity: Expressed on B-cells. Post-translational modification: Phosphorylated. Might be functionally regulated by protein kinase(s). Involvement in disease: Immunodeficiency, common variable, 5 (CVID5) [MIM:613495]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10. Pharmaceutical use: Monoclonal antibodies (mAb) against CD20 are used to treat B-cell non-Hodgkin lymphoma (NHL). These antibodies include Rituximab (Mabthera), Britumomab (Zevalin) and Tositumomab (Bexxar). CD20 engaged by mAb can generate transmembrane signals capable of directly controlling cell growth and triggering cell death in certain tumors. Alternatively, mAb can mediate complement-dependent cytotoxicity. Sequence similarities: Belongs to the MS4A family. Caution: Epitope 1, mapped in Ref.8, is predicted to be buried in the membrane. Its accessibility to the extracellular space, and thus to antibody recognition, is not explained.

7 ml

345 USD