product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti - Cytokeratin 19
catalog :
MBS684039
quantity :
1 ml (Prediluted)
price :
175 USD
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
E16-L
reactivity :
human
application :
immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS684039
products type :
Antibody
products full name :
Anti - Cytokeratin 19
products short name :
Cytokeratin 19
other names :
Keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 19; keratin, type I cytoskeletal 19; CK-19; keratin-19; cytokeratin 19; cytokeratin-19; keratin, type I, 40-kd; 40-kDa keratin intermediate filament; keratin 19; Cytokeratin-19; CK-19; Keratin-19
other gene names :
KRT19; KRT19; K19; CK19; K1CS; CK-19; K19
uniprot entry name :
K1C19_HUMAN
clonality :
Monoclonal
clone :
E16-L
host :
Rabbit
sequence length :
400
specificity :
Human
storage stability :
Store at +4 degree C. Do not freeze!
tested application :
Immunohistochemistry (IHC) - Formalin/Paraffin
app notes :
IHC-P dilution 1:100 - 1:200; IHC-Fr application and dilution to be tested by the user. Postitive Control: Liver tissue, colon adenocarcinoma tissue.
other info1 :
Immunogen: Peptide derived from C-terminal region of human cytokeratin 19. Antibody recognizes the epitope between Gly386-Val399. Stabilizer: 20 mg/ml BSA. Cellular localization: cytoplasm. Protein accession number: P08727
other info2 :
Preservative: 0.05% NaN3. Regulatory Status: ISO 9001:2008, ISO 13485:2003, CES. Storage Buffer: 20 mM Tris-HCI, pH 8.0
ncbi gi num :
311033484
ncbi acc num :
P08727.4
uniprot acc num :
P08727
ncbi mol weight :
44,106 Da
ncbi summary :
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Ref.14. Subunit structure: Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein. Ref.13 Ref.14. Tissue specificity: Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin. Ref.2 Ref.4 Ref.14. Developmental stage: Present in hair follicles at all stages of development. Ref.4. Domain: This keratin differs from all other IF proteins in lacking the C-terminal tail domain. Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Sequence similarities: Belongs to the intermediate filament family.
size1 :
1 ml (Prediluted)
price1 :
175 USD
size2 :
0.04 mL
price2 :
185
size3 :
0.1 mL
price3 :
275
size4 :
7 ml (Prediluted)
price4 :
285
size5 :
0.2 mL
price5 :
340
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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