This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
Anti - CD 10
catalog :
MBS684028
quantity :
7 ml
price :
345 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human
application :
immunohistochemistry, immunohistochemistry - paraffin section
product information
catalog number :
MBS684028
products type :
Antibody
products full name :
Anti - CD 10
products short name :
CD 10
other names :
Neprilysin; Neprilysin; neprilysin; enkephalinase; atriopeptidase; neprilysin-390; neprilysin-411; skin fibroblast elastase; neutral endopeptidase 24.11; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; common acute lymphocytic leukemia antigen; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase); membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); membrane metallo-endopeptidase; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase
products gene name :
CD 10
other gene names :
MME; MME; NEP; SFE; CD10; CALLA; EPN; CALLA; NEP; Neutral endopeptidase; SFE
uniprot entry name :
NEP_HUMAN
clonality :
Monoclonal
clone :
E19-P
host :
Rabbit
reactivity :
Human
sequence length :
750
specificity :
Human
storage stability :
Store at +4 degree C.
tested application :
Immunohistochemistry (IHC) - Formalin/Paraffin
app notes :
IHC-P dilution 1:100 - 1:200; IHC-Fr application and dilution to be tested by the user
other info1 :
Immunogen: Peptide derived from C-terminal sequence of human CD 10. Storage Buffer: 20 mM Tris-HCI, pH 8.0. Stabilizer: 20 mg/ml BSA
other info2 :
Preservative: 0.05% NaN3. Regulatory Status: ISO 9001:2008, ISO 13485:2003, CE
ncbi gi num :
128062
ncbi acc num :
P08473.2
uniprot acc num :
P08473
ncbi mol weight :
85,514 Da
ncbi summary :
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Ref.9 Ref.12 Ref.14. Catalytic activity: Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'. Cofactor: Binds 1 zinc ion per subunit. Ref.18 Ref.19. Enzyme regulation: Inhibited in a dose dependent manner by opiorphin. Subcellular location: Cell membrane; Single-pass type II membrane protein. Post-translational modification: Myristoylation is a determinant of membrane targeting.Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity. Miscellaneous: Important cell surface marker in the diagnostic of human acute lymphocytic leukemia. Sequence similarities: Belongs to the peptidase M13 family. Biophysicochemical propertiesKinetic parameters:KM=55.1 uM for angiotensin-1 Ref.12KM=179 uM for angiotensin-2KM=111.4 uM for angiotensin 1-9. Sequence caution: The sequence CAA30157.1 differs from that shown. Reason: Erroneous initiation.
size :
7 ml
price :
345 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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