product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti - iNOS
catalog :
MBS684027
quantity :
1 ml (Prediluted)
price :
175 USD
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
K13-A
reactivity :
human
application :
immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS684027
products type :
Antibody
products full name :
Anti - iNOS
products short name :
iNOS
other names :
Nitric oxide synthase, inducible; Nitric oxide synthase, inducible; nitric oxide synthase, inducible; NOS type II; NOS, type II; inducible NOS; hepatocyte NOS; inducible NO synthase; nitric oxide synthase, macrophage; peptidyl-cysteine S-nitrosylase NOS2; nitric oxide synthase 2A (inducible, hepatocytes); nitric oxide synthase 2, inducible; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2
products gene name :
iNOS
other gene names :
NOS2; NOS2; NOS; INOS; NOS2A; HEP-NOS; NOS2A; HEP-NOS; Inducible NOS; iNOS
uniprot entry name :
NOS2_HUMAN
clonality :
Monoclonal
clone :
K13-A
host :
Rabbit
reactivity :
Human
sequence length :
1153
specificity :
Human
storage stability :
Store at +4 degree C.
tested application :
Immunohistochemistry (IHC) - Formalin/Paraffin
app notes :
IHC-P dilution 1:100 - 1:200; IHC-Fr application and dilution to be tested by the user
other info1 :
Immunogen: Peptide derived from human iNOS sequence . Storage Buffer: 20 mM Tris-HCI, pH 8.0. Stabilizer: 20 mg/ml BSA
other info2 :
Preservative: 0.05% NaN3. Regulatory Status: ISO 9001:2008, ISO 13485:2003, CE
ncbi gi num :
1352513
ncbi acc num :
P35228.2
uniprot acc num :
P35228
ncbi mol weight :
131,117 Da
ncbi summary :
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. Catalytic activity: 2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O. Cofactor: Heme group . By similarity.Binds 1 FAD . By similarity.Binds 1 FMN . By similarity.Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme . By similarity. Enzyme regulation: Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity . By similarity. Subunit structure: Homodimer. Binds SLC9A3R1. Tissue specificity: Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Induction: By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta. Ref.14. Polymorphism: Note=Genetic variations in NOS2 are involved in resistance to malaria [. MIM:611162]. Sequence similarities: Belongs to the NOS family.Contains 1 FAD-binding FR-type domain.Contains 1 flavodoxin-like domain.
size1 :
1 ml (Prediluted)
price1 :
175 USD
size2 :
0.04 mL
price2 :
185
size3 :
0.1 mL
price3 :
370
size4 :
7 ml (Prediluted)
price4 :
400
size5 :
0.2 mL
price5 :
505
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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