Anti - CD 45 | MyBioSource MBS684007 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti - CD 45

catalog :

MBS684007

quantity :

1 ml (Prediluted)

price :

175 USD

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

E19-G

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS684007

products type :

Antibody

products full name :

Anti - CD 45

products short name :

CD 45

other names :

Receptor-type tyrosine-protein phosphatase C; Receptor-type tyrosine-protein phosphatase C; receptor-type tyrosine-protein phosphatase C; CD45 antigen; T200 glycoprotein; T200 leukocyte common antigen; protein tyrosine phosphatase, receptor type, c polypeptide; protein tyrosine phosphatase, receptor type, C; Leukocyte common antigen; L-CA; T200

products gene name :

CD 45

other gene names :

PTPRC; PTPRC; LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; CD45; L-CA

uniprot entry name :

PTPRC_HUMAN

clonality :

Monoclonal

clone :

E19-G

host :

Rabbit

reactivity :

Human

sequence length :

1304

specificity :

Human

storage stability :

Store at +4 degree C.

tested application :

Immunohistochemistry (IHC) - Formalin/Paraffin

app notes :

IHC-P dilution 1:100 - 1:1 000; IHC-Fr application and dilution to be tested by the user

other info1 :

Immunogen: Peptide derived from C-terminal sequence of human CD 45. Storage Buffer: 20 mM Tris-HCI, pH 8.0. Stabilizer: 20 mg/ml BSA

other info2 :

Preservative: 0.05% NaN3. Regulatory Status: ISO 9001:2008, ISO 13485:2003, CE

ncbi gi num :

33112650

ncbi acc num :

P08575.2

uniprot acc num :

P08575

ncbi mol weight :

147,254 Da

ncbi summary :

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

uniprot summary :

Function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity . By similarity. Ref.6 Ref.8. Catalytic activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. Subunit structure: Binds GANAB and PRKCSH . By similarity. Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Ref.8 Ref.9. Subcellular location: Membrane; Single-pass type I membrane protein. Membrane raft. Note: Colocalized with DPP4 in membrane rafts. Ref.9. Domain: The first PTPase domain interacts with SKAP1. Post-translational modification: Heavily N- and O-glycosylated. Involvement in disease: Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.16 Ref.17Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry. Ref.16. Sequence similarities: Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.Contains 2 fibronectin type-III domains.Contains 2 tyrosine-protein phosphatase domains.

size1 :

1 ml (Prediluted)

price1 :

175 USD

size2 :

0.04 mL

price2 :

185

size3 :

0.1 mL

price3 :

315

size4 :

7 ml (Prediluted)

price4 :

335

size5 :

0.2 mL

price5 :

415

more info or order :

MyBioSource product webpage