protein

Human C-Reactive Protein (rCRP)

MBS682144

1 mg

290 USD

Recombinant Protein

Human C-Reactive Protein (rCRP)

Human C-Reactive Protein

Human C-Reactive Protein; rCRP (human)

CRP; C-reactive protein; C-reactive protein; pentraxin 1; OTTHUMP00000033307; C-reactive protein, pentraxin-related

CRP

CRP; CRP; PTX1; MGC88244; MGC149895; PTX1

CRP_HUMAN

E.coli

SDS-PAGE. a single band (1 ug/lane)

Liquid

1mg/mL (calculated by spectrophotometry, epsilon280nm of 1% solution = 17).

2~10 degree C.

Standard: rhCRP-04

Appearance: Clear solution. State: Solution

r-hCRP is produced into culture medium by DNA recombinant procedure in E. Coli as secretory protein. By expressing kil gene, the outer membrane of E. Coli becomes permeable, allowing r-hCRP to be excreted without cell lysis. r-hCRP has similar biological property in terms of Ca 2+ -binding ability to the native protein, and is purified by affinity chromatography. N-terminal amino acid sequence of r-hCRP is the same as that of the native human CRP.

17975775

P02741

25,039 Da

Classical Antibody-mediated Complement Activation Pathway (106409); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); IL6-mediated Signaling Events Pathway (137932); Immune System Pathway (106386); Initial Triggering Of Complement Pathway (106406); Innate Immunity Signaling Pathway (106387); Selenium Pathway (198825)

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq]

Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Cofactor: Binds 2 calcium ions per subunit. Subunit structure: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Subcellular location: Secreted. Tissue specificity: Found in plasma. Induction: The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6//interleukin-6. Miscellaneous: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium. Sequence similarities: Belongs to the pentaxin family.Contains 1 pentaxin domain. Mass spectrometry: Molecular mass is 23028 Da from positions 19 - 224. Determined by MALDI. Ref.15Molecular mass is 22930 Da from positions 19 - 223. Determined by MALDI. Ref.15

1 mg

290 USD