protein

Alkaline Phosphatase (ALP-5000)

MBS682024

1 mg

325 USD

Enzyme

Alkaline Phosphatase (ALP-5000)

Alkaline Phosphatase

Alkaline Phosphatase; ALP, >5,000IU/mg

alkaline phosphatase; Alkaline phosphatase, tissue-nonspecific isozyme; alkaline phosphatase, tissue-nonspecific isozyme; OTTHUMP00000002971; OTTHUMP00000002972; glycerophosphatase; tissue-nonspecific ALP; alkaline phosphomonoesterase; liver/bone/kidney-type alkaline phosphatase; alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; Alkaline phosphatase liver/bone/kidney isozyme

ALP

ALPL; ALPL; HOPS; TNAP; APTNAP; TNSALP; AP-TNAP; FLJ40094; FLJ93059; MGC161443; MGC167935

PPBT_HUMAN

524

50% Glycerol Solution

Specifications: Alkaline Phosphatase from Calf intestine for enzyme immunoassay. orthophosphoric-monoester phosphohydrolase (alkaline optimum) (EC 3.1.3.1)

State: Highly purified enzyme in solution. 1mL of solution contains the following. Protein (10 - 15 mg). Glycerol (50%). MgCl 2 (5.0mM +/- 5%). ZnCl 2 (0.1mM +/- 5%). Tris-HCl (10mM +/- 5%). pH (7.5 +/- 0.5)

Enzymes

178462

P05186

57,305 Da

Endochondral Ossification Pathway (198812); Folate Biosynthesis Pathway (83018); Folate Biosynthesis Pathway (404); Metabolic Pathways (132956); TNF-alpha/NF-kB Signaling Pathway (198884)

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq]

Function: This isozyme may play a role in skeletal mineralization. Catalytic activity: A phosphate monoester + H2O = an alcohol + phosphate. Cofactor: Binds 1 magnesium ion. By similarity.Binds 2 zinc ions. Subunit structure: Homodimer. Subcellular location: Cell membrane; Lipid-anchor GPI-anchor Ref.10 Ref.11. Post-translational modification: Glycosylated. Ref.9 Ref.12. Involvement in disease: Defects in ALPL are a cause of hypophosphatasia (HOPS) [. MIM:146300]. HOPS is an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto). Ref.4 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24 Ref.25 Ref.26 Ref.27 Ref.28 Ref.29 Ref.30 Ref.31 Ref.32 Ref.33 Ref.34 Ref.35Defects in ALPL are a cause of hypophosphatasia childhood type (HOPSC) [. MIM:241510].Defects in ALPL are a cause of hypophosphatasia infantile type (HOPSI) [. MIM:241500]. Sequence similarities: Belongs to the alkaline phosphatase family. Sequence caution: The sequence BAD93051.1 differs from that shown. Reason: Erroneous initiation.

1 mg

325 USD