This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
mAb to NusA
catalog :
MBS680039
quantity :
0.1 mL
price :
380 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1NA1
reactivity :
Escherichia coli str. K-12 substr. MG1655
application :
western blot, ELISA, enzyme immunoassay
product information
catalog number :
MBS680039
products type :
Antibody
products full name :
mAb to NusA
products short name :
NusA
products name syn :
MAb to NusA subunit of E.coli RNA polymerase; E. coli RNA NusA Monoclonal Antibody; L factor; N utilization substance protein A; Transcription elongation protein nusA
other names :
transcription termination/antitermination L factor; Transcription termination/antitermination protein NusA; transcription termination/antitermination L factor; N utilization substance protein A; Transcription termination/antitermination L factor
products gene name :
NusA
other gene names :
nusA; nusA; ECK3158; JW3138
uniprot entry name :
NUSA_ECOLI
clonality :
Monoclonal
isotype :
IgG2b
clone :
1NA1
host :
Mouse
reactivity :
E Coli
sequence positions :
343-494
sequence length :
495
specificity :
NusA (E. coli NusA)
form :
Ascites
storage stability :
Store at -20 degree C
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
Western Blot: Yes - dilute at 1:1000
other info1 :
Immunogen: Recombinant Protein. Reported Reactivity: Salmonella typhimurium, Serratia marcescens. Cross Reactivity Note: Salmonella typhimurium, Serratia marcescens
other info2 :
Polyol-responsive: Yes. Reconstitution: Add 100ul of ddH2O to the tube containing antibody and mix to dissolve. Product Note: Does not react with B. cereus nor B. subtilis. *Cross reactivity and Applications data is per published literature and/or unpublished data.
products description :
MAb to NusA subunit of E.coli RNA polymerase. NusA is a 64 kDA component of the E. coli transcription machinery involved in elongation termination. NusA is a 64kDa component of E. coli transcription machinery involved in elongation termination. NusA is a 64kDa component of the E. coli transcription machinery involved in elongation termination. Participates in both the termination and antitermination of transcription. NusA binds directly to the core enzyme of the DNA-dependent RNA polymerase. NusA also interacts with lambda N protein, RNA, rho factor, and perhaps nusB. Binds RNA.
ncbi gi num :
16131061
ncbi acc num :
NP_417638
ncbi gb acc num :
NC_000913.2
uniprot acc num :
P0AFF6
ncbi mol weight :
54,871 Da
ncbi summary :
Transcription termination/antitermination L factor (NusA) is a key component in both prevention and enhancement of transcriptional termination. [More information is available at EcoCyc: EG10665].
uniprot summary :
Function: Participates in both transcription termination and antitermination. Involved in a variety of cellular and viral termination and antitermination processes, such as Rho-dependent transcriptional termination, intrinsic termination, and phage lambda N-mediated transcriptional antitermination. Also important for coordinating the cellular responses to DNA damage by coupling the processes of nucleotide excision repair and translesion synthesis to transcription. Ref.8 Ref.9 Ref.10 Ref.13 Ref.15 Ref.17 Ref.18 Ref.20 Ref.21. Subunit structure: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA. Also interacts with the termination Rho factor and the phage lambda N protein. Ref.7 Ref.8 Ref.11 Ref.14 Ref.15. Subcellular location: Cytoplasm. Note: Colocalizes with nucleoids. Ref.19. Induction: In response to low temperature. Negatively autoregulated. Ref.3 Ref.12. Domain: The N-terminal region interacts with RNA polymerase. The central region is composed of 3 RNA binding domains, S1, KH 1 and KH 2. The C-terminal region contains 2 acidic repeats, AR1 and AR2, which bind to protein N from phage lambda during antitermination. Ref.21 Ref.22 Ref.23. Disruption phenotype: Mutants are sensitive to DNA-damaging agents. Ref.20. Sequence similarities: Belongs to the NusA family.Contains 2 KH domains.Contains 1 S1 motif domain.
size1 :
0.1 mL
price1 :
380 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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