antibody

Mouse Anti-Human CD36-UNLB

MBS674242

0.1 mg

170 USD

monoclonal

mouse

nonconjugated

SMf

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

Secondary Antibody

Mouse Anti-Human CD36-UNLB

CD36

Mouse Anti-Human CD36 - Purified, Unlabeled Antibody; Mouse Anti-Human CD36

CD36; Platelet glycoprotein 4; platelet glycoprotein 4; GPIIIB; PAS IV; PAS-4 protein; glycoprotein IIIb; OTTHUMP00000207872; OTTHUMP00000207874; OTTHUMP00000207879; OTTHUMP00000207881; OTTHUMP00000207938; OTTHUMP00000229733; cluster determinant 36; fatty acid translocase; platelet glycoprotein IV; scavenger receptor class B, member 3; leukocyte differentiation antigen CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor); Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Platelet glycoprotein IV; GPIV; Thrombospondin receptor

CD36; CD36; FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; GP3B; GP4

CD36_HUMAN

Monoclonal

Mouse IgM

SMf

Mouse

Human

54

Human CD36. CD36, also known as GPIV, is an 88 kDa glycoprotein that is a receptor for extracellular matrix proteins such as collagen and thrombospondin. Its expression is restricted to platelets, monocytes, macrophages, erythrocyte precursors, adipocytes, activated keratinocytes, and some endothelial and epithelial cells. CD36 is a multifunctional protein that has roles as a cell adhesion molecule, a scavenger receptor, a signal transducer and in the pathogenesis of malaria via its affinity for Plasmodium falciparum erythrocyte membrane protein 1 (PEMP1). CD36 on macrophages functions in the phagocytic clearance of apoptotic cells.1-4

Purified (UNLB) Antibody

The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0. Store at 2-8 degree C. The fluorescein (FITC) conjugate is supplied as 100 tests in 1.0 mL of PBS/NaN3. Store at 2-8 degree C. Protect conjugated forms from light. Reagents are stable for the period shown on the label if stored as directed.

Flow Cytometry; Immunohistochemistry (Frozen Sections); Western Blot

Flow Cytometry Suggested Dilution: <= 1 ug/10^6 cells

Characterization: To insure lot to lot consistency, each batch of product is tested by flow cytometry to conform with the characteristics of a standard reference reagent.

1. Knapp, W., B. Dorken, W.R. GIlks, E.P. Rieber, R.E. Schmidt, H. Stein, A.E.G.K. Von dem Borne, eds. 1989. Leukocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD36 Section, Academic Press, New York, p. 221. 3. Yeung, C.H., F. Perez-Sanchez, S. Schroter, C. Kirchhoff, and T.G. Cooper. 2001. Mol. Hum. Reprod. 7:617. 4. Greenwalt, D.E., R.H. Lipsky, C.F. Ockenhouse, H. Ikeda, N.N. Tandon, and G.G. Jamieson. 1992. Blood 80:1105.

12620274

P16671

53,053 Da

Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!Collagen Adhesion Via Gp IV Pathway 106032!!Diabetes Pathways 105902!!ECM-receptor Interaction Pathway 83068!!ECM-receptor Interaction Pathway 479!!Fat Digestion And Absorption Pathway 194385!!Fat Digestion And Absorption Pathway 194324!!Formation Of Platelet Plug Pathway 106029!!Hematopoietic Cell Lineage Pathway 83078

The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

Function: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic efects. Ref.20 Ref.22. Subunit structure: Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Ref.12. Subcellular location: Membrane; Multi-pass membrane protein. Post-translational modification: N-glycosylated and O-glycosylated with a ratio of 2:1. Ref.8 Ref.14 Ref.15 Ref.16. Polymorphism: Genetic variation in CD36 influences the severity and outcome of malaria infection. Involvement in disease: Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[. MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Ref.17 Ref.21Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [. MIM:610938]. Ref.23. Sequence similarities: Belongs to the CD36 family. Sequence caution: The sequence AAM14636.2 differs from that shown. Reason: Frameshift at position 53.

0.1 mg

170 USD