antibody

Mouse Anti-Human IL-25-UNLB

MBS670216

0.5 mg

340 USD

monoclonal

mouse

nonconjugated

SB129e1

Antibody

Mouse Anti-Human IL-25-UNLB

IL-25

Mouse anti-Human Interleukin-25 (IL-25)

interleukin-25 isoform 2; Interleukin-25; interleukin-25; interleukin-17E; interleukin 25; Interleukin-17E

IL25; IL25; IL17E; IL17E; IL-25; IL-17E

IL25_HUMAN

Monoclonal

IgG2b

SB129e1

Mouse

Human

Reacts with native and recombinant human IL-251. Interleukin-25 (IL-25), also known as IL-17E, is a 17kD protein and a recently identified member of the IL-17 cytokine family. This cytokine is secreted by a variety of cells, including type 2 helper T cells (Th2), bone marrow-derived mast cells and alveolar macrophages2. On target cells, IL-25 can induce the production of several type 2 cytokines including IL-4, IL-5 and IL-13 and implicates a role for this cytokine in type 2 immune response3. Studies have linked this cytokine to promoting airway hyperreactivity, limiting pro inflammatory cytokine production and chronic intestinal inflammation and providing protective immunity following intestinal helminth infection4-6.

Purified (UNLB) Antibody

The purified (UNLB) antibody is supplied as 0.5mg purified immunoglobulin in 1.0mL of 100mM borate buffered saline, pH 8.2; store at 2-8 degree C. Reagents are stable for the period shown on the label if stored as directed.

ELISA

ELISA: 0.1 - 1.0ug/mL

Immunogen: Recombinant Human IL-25. Characterization: To ensure acceptable performance, each batch of product is tested by ELISA to conform to characteristics of a standard reference reagent.

1) Kleinschek, M.A. et al. (2007). J. Exp. Med. 204:161-70. 3) Fort, M.M. et al. (2001). Immunity. 15:985-95. 4) Owyang, A.M. et al. (2006). J. Exp. Med. 203:1105-16. 5) Stock, P. et al. (2009). J. Immunol. 182:5116-22. 6) Perrigoue, J.G. et al. (2008). Cell Microbiol. 10:1757-64.

27477081

NP_758525.1

NM_172314.1

Q9H293

20,330 Da

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460)

The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Function: Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses. Subcellular location: Secreted. Tissue specificity: Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea. Sequence similarities: Belongs to the IL-17 family.

0.5 mg

340 USD