Mouse Anti-Human MMP-2-UNLB | MyBioSource MBS670150 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti-Human MMP-2-UNLB

catalog :

MBS670150

quantity :

0.1 mg

price :

265 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SB13a

reactivity :

human, rat

application :

ELISA

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS670150

products type :

Antibody

products full name :

Mouse Anti-Human MMP-2-UNLB

products short name :

MMP-2

products name syn :

Mouse Anti-Human MMP-2 - Purified, Unlabeled Antibody; Mouse Anti-Human MMP-2

other names :

MMP-2; MMP-2; 72 kDa type IV collagenase; MMP-2; gelatinase A; 72 kDa gelatinase; matrix metalloproteinase 2; matrix metalloproteinase-2; matrix metallopeptidase 2

other gene names :

Mmp2; Mmp2; Mmp2; MMP-2

uniprot entry name :

Q9JHC2_RAT

clonality :

Monoclonal

isotype :

Mouse IgG1

clone :

SB13a

host :

Mouse

reactivity :

Human

sequence length :

specificity :

Human MMP-2; Does not cross react to human MMP-1, MMP-3 or MMP-9. Matrix metalloproteinases (MMPs) are a family of at least 20 structurally related, zinc-containing enzymes that have the ability to breakdown connective tissue. MMP-2 is also known as gelatinase A, 72 kDa gelatinase, type IV collagenase and TBE-1. MMP-2, along with MMP-9, belongs to the gelatinase group of MMP's which have three repeats of a type II fibronectin domain inserted in the catalytic domain. MMP-2 has shown direct and indirect substrate specificity to collagens I, IV, V, VII, X and XIV, gelatin, elastin, laminin-1, laminin-5, myelin basic protein, MMP-1, MMP-9, and MMP-13. 1-15

form :

Purified (UNLB) Antibody

storage stability :

The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 0.2 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C. • The horseradish peroxidase (HRP) conjugate is supplied as 1.0 mL of stock solution in 50% glycerol/50% PBS, pH 7.4. No preservative added. Store at 2-8 degree C or long-term at -20 degree C. • Reagents are stable for the period shown on the label if stored as directed.

tested application :

ELISA; Immunohistochemistry_PES

app notes :

Immunohistochemistry Suggested Dilution: ELISA Suggested Dilution: 1:3,000-1:8,000

other info1 :

Immunogen: Recombinant MMP-2

other info2 :

Characterization: To insure lot-to-lot consistency, each batch of product is tested by ELISA to conform with the characteristics of a standard reference reagent.

products references :

1. Steffensen, B., U.M. Wallon, and C.M. Overall. 1995. J. Biol. Chem. 270:11555. 2. Collier, I.E., S.M. Wilhelm, A.Z. Eisen, B.L. Marmer, G.A. Grant, J.L. Seltzer, A. Kronberger, C. He, E.A. Bauer, and G.L. Goldberg. 1988. J. Biol. Chem. 263:6579. 3. Allan, J.A., A.J. Docherty, P.J. Barker, N.S. Huskisson, J.J. Reynolds, and G. Murphy. 1995. Biochem. J. 309:229. 4. Seltzer, J.L., A.Z. Eisen, E.A. Bauer, N.P. Morris, R.W. Glanville, and R.E. Burgeson. 1989. J. Biol. Chem. 264:3822. 5. Aimes, R.T., and J.P. Quigley. 1995. J. Biol. Chem. 270:5872. 6. Murphy, G., M.I. Cockett, R.V. Ward, and A.J. Docherty. 1991. Biochem. J. 277:277. 7. Welgus, H.G., C.J. Fliszar, J.L. Seltzer, T.M. Schmid, and J.J. Jeffery. 1990. J. Biiol. Chem. 265:13521. 8. Sires, U.I., B. Dublet, E. Aubert-Foucher, M. van der Rest, and G.G. Welgus. 1995. J. Biol. Chem. 270:1062. 9. Senior, R.M., G.L. Griffin, C.J. Fliszar, S.D. Shapiro, G.I. Goldberg, and H.G. Welgus. 1991. J. Biol. Chem. 266:7870. 10. Khan, K.M., G.W. Laurie, T.A. McCaffrey, and D.J. Falcone. 2002. J. Biol. Chem. 277:13778. 11. Giannelli, G., J. Falk-Marzillier, O. Schiraldi, W.G. Stetler-Stevenson, and V. Quaranta. 1997. Science 277:225. 12. Chandler, S., R. Coates, A. Gearing, J. Lury, G. Wells, and E. Bone. 1995. Neurosci. Lett. 201:223. 13. Crabbe, T., J.P. O'Connell, B.J. Smith, and A.J. Docherty. 1994. Biochemistry 33:14419. 14. Fridman, R., M. Toth, D. Pena, and S. Mobashery. 1995. Cancer Res. 55:2548. 15. Knauper, V., H. Will, C. Lopez-Otin, B. Smith, S.J. Atkinson, H. Stanton, R.M. Hembry, and G. Murphy. 1996. J. Biol. Chem. 271:17124.

ncbi gi num :

8050250

uniprot acc num :

Q9JHC2

ncbi mol weight :

3,196 Da

ncbi pathways :

Bladder Cancer Pathway 83503!!Bladder Cancer Pathway 527!!GnRH Signaling Pathway 83483!!GnRH Signaling Pathway 502!!IL-3 Signaling Pathway 198504!!Leukocyte Transendothelial Migration Pathway 83475!!Leukocyte Transendothelial Migration Pathway 494!!Matrix Metalloproteinases Pathway 198492!!Pathways In Cancer 83493

ncbi summary :

plays important roles in wound healing, angiogenesis, platelet aggregation, and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli [RGD]

size :

0.1 mg

price :

265 USD

more info or order :

MyBioSource product webpage