antibody

Monoclonal Antibody to hPD-L1 (Clone: ABM4E54) PE Conjugated

MBS669028

100 Tests

290 USD

monoclonal

mouse

PE

[ABM4E54]

flow cytometry, FACS

Antibody

Monoclonal Antibody to hPD-L1 (Clone: ABM4E54) PE Conjugated

[hPD-L1]

[B7 homolog 1]

[programmed cell death 1 ligand 1 isoform b; Programmed cell death 1 ligand 1; programmed cell death 1 ligand 1; CD274 molecule; B7 homolog 1; B7-H1; CD_antigen: CD274]

[hPD-L1]

[CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1]

[CD274; CD274; B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1; B7H1; PDCD1L1; PDCD1LG1; PDL1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7-H1]

Monoclonal

IgG2a Kappa

[ABM4E54]

Mouse

Human

176

Protein G Chromatography

Purified. 25 Test in 125 ul/100 Test in 500 ?l PBS containing 0.05% sodium azide. Sodium azide is highly toxic.

Store the antibody at 4°C; stable for 6 months.

Flow Cytometry (FC/FACS)

FC/FACS: 1-2 ug/ml

Flow Cytometry (FC/FACS)

Immunogen Information: A partial length recombinant PDL1 protein (amino acids 18-227) was used as the immunogen for this antibody.

Cancer Marker

PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belongs to the B7 superfamily that inhibits immune responses through its receptor, PD-1 and PD-L1 play a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation and in numerous autoimmune diseases.

390979639

NP_001254635.1

NM_001267706.1

Q9NZQ7

Adaptive Immune System Pathway (366160); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Costimulation By The CD28 Family Pathway (119552); Immune System Pathway (106386); PD-1 Signaling Pathway (119557)

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.

100 Tests

290 USD