catalog number :
MBS668938
products full name :
Monoclonal Antibody to CREB (Clone: ABM13H8)
products short name :
[CREB]
products name syn :
[CREB1; Cyclic AMP-responsive element-binding protein 1]
other names :
[cyclic AMP-responsive element-binding protein 1 isoform A; Cyclic AMP-responsive element-binding protein 1; cyclic AMP-responsive element-binding protein 1; cAMP responsive element binding protein 1]
products gene name :
[CREB]
products gene name syn :
[CREB1]
other gene names :
[CREB1; CREB1; CREB; CREB-1; CREB-1; cAMP-responsive element-binding protein 1]
purity :
Protein G Purification
form :
Purified; 100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
storage stability :
Store the antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeat freezing and thawing
tested application :
Flow Cytometry (FC/FACS)
app notes :
FC/FC/FACS: 0.5-1 ug/ 10^6 cells
image1 heading :
Flow Cytometry (FC/FACS)
other info1 :
Immunogen Information: A partial length recombinant CREB protein (amino acids 87-292) was used as the immunogen for this antibody.
products categories :
Apoptosis
ncbi acc num :
NP_004370.1
ncbi gb acc num :
NM_004379.4
ncbi pathways :
AKT Phosphorylates Targets In The Nucleus Pathway (106476); ATF-2 Transcription Factor Network Pathway (138006); Activated TLR4 Signalling Pathway (106400); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Adaptive Immune System Pathway (366160); Adipogenesis Pathway (198832); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546)
ncbi summary :
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
uniprot summary :
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.