antibody

Polyclonal Antibody to Filaggrin-1

MBS668648

0.1 mg

270 USD

polyclonal

rabbit

nonconjugated

Antibody

Polyclonal Antibody to Filaggrin-1

[Filaggrin-1]

[FLG; Filaggrin]

[Filaggrin; Filaggrin; filaggrin; filaggrin]

[FLG]

[FLG; FLG; ATOD2]

Polyclonal

IgG

Rabbit

Human

4061

Purified. Protein A Chromatography

25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Western Blot (WB)

WB: 0.1-0.5 ug/ml

Western Blot (WB)

Immunogen Information: A partial length recombinant Filaggrin-1 protein (amino acids 1-300) was used as the immunogen for this antibody.

Antibodies; Cancer Marker

84028206

P20930.3

P20930

AhR Pathway (755436)

The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]

FLG: Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. Defects in FLG are the cause of ichthyosis vulgaris (VI); also known as ichthyosis simplex. Ichthyosis vulgaris is the most common form of ichthyosis inherited as an autosomal dominant trait. It is characterized by palmar hyperlinearity, keratosis pilaris and a fine scale that is most prominent over the lower abdomen, arms, and legs. Ichthyosis vulgaris is characterized histologically by absent or reduced keratohyalin granules in the epidermis and mild hyperkeratosis. The disease can be associated with frequent asthma, eczema or hay fever. Defects in FLG are a cause of susceptibility to dermatitis atopic type 2 (ATOD2). Atopic dermatitis is a complex, inflammatory disease with multiple alleles at several loci thought to be involved in the pathogenesis. It commonly begins in infancy or early childhood and is characterized by a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry skin, and IgE- mediated sensitization to food and environmental allergens. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. Belongs to the S100-fused protein family. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 1q21.3. Cellular Component: intracellular membrane-bound organelle; nucleus. Molecular Function: protein binding. Biological Process: keratinocyte differentiation. Disease: Dermatitis, Atopic, 2; Ichthyosis Vulgaris

0.1 mg

270 USD