catalog number :
MBS668481
products full name :
Monoclonal Antibody to TSLP (Clone: ABM27H9)
products short name :
[TSLP]
products name syn :
[Thymic stromal lymphopoietin]
other names :
[Cytokine receptor-like factor 2; Cytokine receptor-like factor 2; cytokine receptor-like factor 2; cytokine receptor-like factor 2; Cytokine receptor-like 2; IL-XR; Thymic stromal lymphopoietin protein receptor; TSLP receptor]
products gene name :
[TSLP]
other gene names :
[CRLF2; CRLF2; CRL2; TSLPR; CRLF2Y; CRL2; ILXR; TSLPR; TSLP receptor]
reactivity :
Mouse, Human
purity :
Purified. Protein G Chromatography
form :
25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
storage stability :
Store the antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles.
tested application :
Western Blot (WB), Flow Cytometry (FC/FACS)
app notes :
WB: 2-4 ug/ml. FACS: 0.5-1 ug/10^6
image1 heading :
Western Blot (WB)
image2 heading :
Flow Cytometry (FC/FACS)
other info1 :
Immunogen Information: Full length recombinant protein of TSLP was used as the immunogen for this antibody.
other info2 :
Antigen: TSLP
products categories :
Antibodies; Immunology
ncbi mol weight :
29,360 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); TSLP Signaling Pathway (672451)
ncbi summary :
This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
uniprot summary :
CRLF2: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: Xp22.33 and Yp11.2