antibody

MERS-CoV Spike (S) protein

MBS668218

0.1 mg

290 USD

monoclonal

house mouse

nonconjugated

[ABM4A80]

Antibody

MERS-CoV Spike (S) protein

[MERS-CoV Spike]

[S protein; S protein]

[MERS]

W5ZZU6_9BETC

Monoclonal

IgG2b Kappa

[ABM4A80]

Mouse

442

Protein G chromatography

25ug in 50ul/100ug in 200ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Western Blot (WB)

Western blot: 0.5-1 ug/ml

Western Blot (WB)

Immunogen: A recombinant protein fragment of MERS-CoV Spike (S) protein was used as the immunogen for this antibody.

The MERS-CoV spike (S) protein is a type I transmembrane glycoprotein which contains 1353 amino acids and can be cleaved into two subunit S1 and S2. It forms large protruding spikes on the surface of the virus. The S1 subunit which contains RBD is responsible for binding to Dipeptidyl peptidase 4, which serves as the host cell receptor of MERS-CoV and S2 mediates the membrane fusion. In this process, heptad repeats 1 and 2 (HR1 and HR2) of the S protein assemble into a complex called six-helix bundle (6-HB) fusion core structure, which represents a key membrane fusion architecture. Importantly, the S protein is considered a key component of vaccines against coronavirus infection, including severe acute respiratory syndrome (SARS).

A0A0U2MS74

0.1 mg

290 USD