CD161 Monoclonal Antibody | MyBioSource MBS668177 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CD161 Monoclonal Antibody

catalog :

MBS668177

quantity :

0.1 mg

price :

175 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[ABM2D74]

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Expression analysis of CD161. Anti-CD161 antibody (Clone: ABM2D74) was tested at 2 ug/ml on Jurkat lysate.

image 2 :

Immunohistochemical analysis of CD161 in small cell carcinoma of esophagus using CD161 antibody (Clone: ABM2D74) at 5 ug/ml.

image 3 :

Immunohistochemical analysis of CD161 in Transitional cell carcinoma of urinary bladder using CD161 antibody (Clone: ABM2D74) at 5 ug/ml.

product information

catalog number :

MBS668177

products type :

Antibody

products full name :

CD161 Monoclonal Antibody

products short name :

[CD161]

other names :

[killer cell lectin-like receptor subfamily B member 1; Killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B, member 1; C-type lectin domain family 5 member B; HNKR-P1a; NKR-P1A; Natural killer cell surface protein P1A; CD_antigen: CD161]

products gene name :

[CD161]

other gene names :

[KLRB1; KLRB1; NKR; CD161; CLEC5B; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A; CLEC5B; NKRP1A; NKR-P1A]

uniprot entry name :

KLRB1_HUMAN

clonality :

Monoclonal

isotype :

Mouse IgG1, Kappa

clone :

[ABM2D74]

host :

Mouse

reactivity :

Human

purity :

Protein G chromatography

form :

Purified (Liquid)

concentration :

0.5 mg/ml

storage stability :

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Westen Blot analysis: 2-4 ug/ml. Immunohistochemical analysis: 5 ug/ml

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

image4 heading :

Flow Cytometry

image4 description :

Cell Surface flow analysis of hCD161 in PBMC (Lymphocytes) using 0.2ug/10^6 cells of CD161 clone (ABM2D74). Green represents isotype control; red represents anti-hCD161 antibody. Goat anti-mouse PE conjugated secondary antibody was used.

other info1 :

Immunogen: A full length of human CD161 protein were used as the immunogen for this antibody.

other info2 :

Content: 25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% and 0.05% sodium azide. Sodium azide is highly toxic.

products categories :

Immunology

products description :

CD161 is the human equivalent of mouse NK cell receptor P1A. It is a type II transmembrane glycoprotein with characteristics of the C-type lectin super family. The expression confines to lymphocytes found in human gut and liver, as well as blood, especially NK (natural killer) cells, Th17 (T helper 17) cells, and a population of unconventional T cells known as MAIT (mucosal-associated invariant T) cells. CD161 promotes T cell expansion and eventually has been identified as a marker of human IL-17-producing T cells. It plays a pivotal role in trans-endothelial migration and is also implicated in the pathogenesis of RA (rheumatoid arthritis) as well as graft-versus-host disease (GVHD).

ncbi gi num :

4504879

ncbi acc num :

NP_002249.1

ncbi gb acc num :

NM_002258.2

uniprot acc num :

Q12918

ncbi pathways :

Malaria Pathway (152665); Malaria Pathway (152657)

ncbi summary :

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]

uniprot summary :

KLRB1: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 12p13. Cellular Component: plasma membrane; integral to membrane. Molecular Function: transmembrane receptor activity; carbohydrate binding. Biological Process: cell surface receptor linked signal transduction

size1 :

0.1 mg

price1 :

175 USD

more info or order :

MyBioSource product webpage