antibody

IL-37 Polyclonal Antibody

MBS668098

0.1 mg

270 USD

polyclonal

rabbit

nonconjugated

Antibody

IL-37 Polyclonal Antibody

[IL-37]

[IL37, FIL1Z, IL1F7, IL1H4, IL1RP1]

[interleukin-37 isoform 1; Interleukin-37; interleukin-37; FIL1 zeta; IL-1 zeta; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL-1X protein; IL1F7 (canonical product IL-1F7b); interleukin 1 family member 7; interleukin 1, zeta; interleukin-1 homolog 4; interleukin-1 superfamily z; interleukin-1-related protein; interleukin-23; interleukin 37; FIL1 zeta; IL-1X; Interleukin-1 family member 7; IL-1F7; Interleukin-1 homolog 4; IL-1H; IL-1H4; Interleukin-1 zeta; IL-1 zeta; Interleukin-1-related protein; IL-1RP1; Interleukin-23; IL-37]

[IL-37]

[IL37; IL37; FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA); FIL1Z; IL1F7; IL1H4; IL1RP1; IL-1F7; IL-1H; IL-1H4; IL-1 zeta; IL-1RP1; IL-37]

IL37_HUMAN

Polyclonal

IgG

Rabbit

Human

218

Protein A Chromatography

Purified

Store the antibody at 4 degree C. stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles.

Western Blot (WB)

Western Blot: 2-4 µg/ml

Western Blot (WB)

Antigen: IL-37

Immunogen: Full length recombinant IL-37 protein was used as the immunogen for this antibody. Content: 25ug in 50ul/100ug in 200ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

Immunology

IL-37 (Interleukin-37) is a member of IL-1 family and is primarily an anti-inflammatory cytokine, which reduces systemic and local inflammation. There are five different splice variants of IL-37 termed IL-37a-e, where Isoform IL-37b is the largest isoform. IL-37 has significant sequence similarity with IL-18 and highly expressed in inflammatory tissues, which inhibits the excessive inflammatory response. The expression is highly induced by several toll-like receptor (TLR) ligands and pro-inflammatory cytokines such as IL-1 beta, TNF-alpha, IFN-gamma. IL-37 is a potent inhibitor of innate immunity by shifting the cytokine equilibrium away from excessive inflammation.

20127524

NP_055254.2

NM_014439.3

Q9NZH6

17,459 Da

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

IL37: Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. Belongs to the IL-1 family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Cytokine. Chromosomal Location of Human Ortholog: 2q12-q14.1. Cellular Component: nucleoplasm; extracellular space; cytoplasm; extracellular region; nucleolus; nucleus; cytosol. Molecular Function: interleukin-1 receptor binding; cytokine activity. Biological Process: cytokine and chemokine mediated signaling pathway; immune response; inflammatory response

0.1 mg

270 USD