NOXA Monoclonal Antibody | MyBioSource MBS668043 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

NOXA Monoclonal Antibody

catalog :

MBS668043

quantity :

0.1 mg

price :

290 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[ABM16G6]

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS668043

products type :

Antibody

products full name :

NOXA Monoclonal Antibody

products short name :

[NOXA]

other names :

[phorbol-12-myristate-13-acetate-induced protein 1; Phorbol-12-myristate-13-acetate-induced protein 1; phorbol-12-myristate-13-acetate-induced protein 1; PMA-induced protein 1; adult T cell leukemia-derived PMA-responsive; immediate-early-response protein APR; protein Noxa; phorbol-12-myristate-13-acetate-induced protein 1; Immediate-early-response protein APR; Protein Noxa]

products gene name :

[NOXA]

other gene names :

[PMAIP1; PMAIP1; APR; NOXA; NOXA; PMA-induced protein 1]

uniprot entry name :

APR_HUMAN

clonality :

Monoclonal

isotype :

Mouse IgG1 kappa

clone :

[ABM16G6]

host :

Mouse

reactivity :

Human (Predicted Reactivity: Mouse

sequence length :

purity :

Protein G Chromatography

form :

100 ug in 200 ul PBS containing 0.05' 0 BSA and 005% sodium azide. Sodium azide is highly toxic.

storage stability :

Store antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.

tested application :

Western Blot (WB)

app notes :

Western Blot Analysis: 2-4ug/ml

image1 heading :

Western Blot (WB)

other info1 :

Antigen: NOXA

other info2 :

Immunogen: A full length recombinant protein was used as the immunogen for this antibody.

products categories :

Apoptosis

products description :

Noxa IS a BH3-only pro-apoptotic protein that mediates apoptosis by specifically inhibiting the anti-apoptotic Bcl-2 family member Mcl-1. It consists of 54 amino aCids with one BH3 domain. The gene for NOXA is a target of p53. In response to cellular stress Noxa is induced by p53 and mediates p53-induced apoptosis But more recently, it has been shown that NOXA can also be induced independently of p53 by other transcription factors such as p73 and E2F1. Noxa is also found to be induced by hypoxia-inducible factor (HIF-1) and mediates HIF-1 induced hypoxic cell death. Noxa is commonly upregulated in melanomas. and is associated with melanoma development and progression. Increase in Noxa expression is driven by oncogenic activation of MEK/ERK signaling through the transcription factor CREB (cAMP responsive element binding protein).

ncbi gi num :

10863923

ncbi acc num :

NP_066950.1

ncbi gb acc num :

NM_021127.2

uniprot acc num :

Q13794

ncbi mol weight :

14,955 Da

ncbi pathways :

Activation Of BH3-only Proteins Pathway (105658); Activation Of NOXA And Translocation To Mitochondria Pathway (105660); Apoptosis Pathway (198797); Apoptosis Pathway (105648); Apoptosis Modulation And Signaling Pathway (198822); BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway (105664); DNA Damage Response Pathway (198788); DNA Damage Response (only ATM Dependent) Pathway (198827); Direct P53 Effectors Pathway (137939); Intrinsic Pathway For Apoptosis (105656)

uniprot summary :

NOXA: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. Interacts with MCL1, BCL2A1 and BAX. Up-regulated by p53/TP53, phorbol esters, double- stranded RNA, IFNB1/IFN-beta and viruses. Highly expressed in adult T-cell leukemia cell line. Belongs to the PMAIP1 family. Protein type: Apoptosis; Mitochondrial. Chromosomal Location of Human Ortholog: 18q21.32. Cellular Component: mitochondrial outer membrane; mitochondrion; cytosol; nucleus. Molecular Function: protein binding. Biological Process: caspase activation; proteasomal protein catabolic process; release of cytochrome c from mitochondria; positive regulation of apoptosis; apoptosis; response to dsRNA; positive regulation of caspase activity; cellular response to glucose starvation; positive regulation of protein oligomerization; negative regulation of fibroblast proliferation; positive regulation of neuron apoptosis; T cell homeostasis; positive regulation of DNA damage response, signal transduction by p53 class mediator; regulation of mitochondrial membrane permeability; defense response to virus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; response to X-ray; response to UV

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage