TLR2 Monoclonal Antibody | MyBioSource MBS668018 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TLR2 Monoclonal Antibody

catalog :

MBS668018

quantity :

0.1 mg

price :

290 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[ABM3A87]

reactivity :

human, mouse

application :

western blot, immunohistochemistry, FACS

more info or order :

MyBioSource product webpage

image

image 1 :

Fig-3: Intracellular flow analysis of TLR2 in PBMC (Monocytes) using 0.5 µg/10^6 cells of TLR2 antibody (Clone: ABM3A87). Green represents isotype control; red represents anti-TLR2 antibody. Goat anti-Mouse PE conjugate was used as secondary.

image 2 :

Fig-4: Intracellular flow analysis of TLR2 in THP-1 cells using 0.5 µg/10^6 cells of TLR2 antibody (Clone: ABM3A87). Green represents isotype control; red represents anti- TLR2 antibody. Goat anti-Mouse PE conjugate was used as secondary antibody.

product information

catalog number :

MBS668018

products type :

Antibody

products full name :

TLR2 Monoclonal Antibody

products short name :

[TLR2]

products name syn :

[TLR2,TIL4]

other names :

[toll-like receptor 2; Toll-like receptor 2; toll-like receptor 2; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4; toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD_antigen: CD282]

products gene name :

[TLR2]

other gene names :

[TLR2; TLR2; TIL4; CD282; TIL4]

uniprot entry name :

TLR2_HUMAN

clonality :

Monoclonal

isotype :

Mouse IgG1, Kappa

clone :

[ABM3A87]

host :

Mouse

reactivity :

Mouse, Human

sequence length :

784

purity :

Protein G Chromatography

form :

Purified. 25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

storage stability :

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

tested application :

IHC, FACS, WB

app notes :

Western blot analysis: 2-4 ug/ml. FACS analysis: 0.5 ug/10^6 cells. Immunohistochemical analysis: 5 ug/ml

image1 heading :

Western Blot (WB)

image2 heading :

Flow Cytometry (FC/FACS)

image3 heading :

Flow Cytometry (FC/FACS) #2 (FC/FACS)

image4 heading :

Immunohistochemistry (IHC)

image4 description :

Immunohistochemical analysis of TLR2 in normal human prostate tissue using TLR2 antibody (Clone: ABM3A87) at 5 ug/ml.

image5 heading :

Immunohistochemical

image5 description :

Immunohistochemical analysis of TLR2 in Renal Cell Carcinoma using TLR2 antibody (Clone: ABM3A87) at 5 ug/ml.

other info1 :

Immunogen: A partial length recombinant TLR2 protein (amino acid 180-420) was used as the immunogen for this antibody.

products categories :

TLR

products description :

TLR2 (Toll-Like Receptors 2) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infection with these pathogens. TLR2 also interacts with a large number of non-TLR molecules, allowing for recognition of a great number and variety of PAMPs (pathogen-associated molecular patterns). TLR2 expression has been detected in immune cells, endothelial, and epithelial cells.

ncbi gi num :

19718734

ncbi acc num :

NP_003255.2

ncbi gb acc num :

NM_003264.3

uniprot acc num :

O60603

ncbi pathways :

Activated TLR4 Signalling Pathway (106400); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Beta Defensins Pathway (530759); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Defensins Pathway (530757); Disease Pathway (530764); Diseases Associated With The TLR Signaling Cascade Pathway (1183537); Diseases Of Immune System Pathway (1183536)

ncbi summary :

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]

uniprot summary :

TLR2: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage- activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1. Interacts with CNPY3. Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues. Belongs to the Toll-like receptor family. Protein type: Cell surface; Membrane protein, integral; Receptor, misc.; Apoptosis; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 4q32. Cellular Component: cell surface; cell projection; integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane. Molecular Function: protein binding; peptidoglycan binding; transmembrane receptor activity; triacylated lipoprotein binding; protein heterodimerization activity; lipopolysaccharide receptor activity; receptor activity; pattern recognition receptor activity; diacylated lipoprotein binding. Biological Process: positive regulation of nitric oxide biosynthetic process; response to toxin; positive regulation of leukocyte migration; positive regulation of NF-kappaB import into nucleus; leukotriene metabolic process; detection of triacylated bacterial lipoprotein; positive regulation of interleukin-10 production; activation of NF-kappaB transcription factor; positive regulation of interferon-beta production; positive regulation of oligodendrocyte differentiation; toll-like receptor 4 signaling pathway; negative regulation of interleukin-12 production; detection of diacylated bacterial lipoprotein; cell surface pattern recognition receptor signaling pathway; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of chemokine production; toll-like receptor 2 signaling pathway; defense response to Gram-positive bacterium; myelin formation in the central nervous system; positive regulation of transcription from RNA polymerase II promoter; response to progesterone stimulus; I-kappaB phosphorylation; positive regulation of nitric-oxide synthase biosynthetic process; apoptosis; positive regulation of interleukin-12 production; microglial cell activation; response to molecule of fungal origin; positive regulation of interleukin-18 production; signal transduction; nitric oxide metabolic process; response to insulin stimulus; positive regulation of interleukin-8 production; negative regulation of cell proliferation; lipopolysaccharide-mediated signaling pathway; inflammatory response; positive regulation of Wnt receptor signaling pathway; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of toll-like receptor signaling pathway; induction by symbiont of defense-related host nitric oxide production; MyD88-dependent toll-like receptor signaling pathway; negative regulation of interleukin-17 production; toll-like receptor signaling pathway; response to hypoxia; innate immune response; immune response; chloramphenicol transport; positive regulation of inflammatory response; positive regulation of cytokine secretion. Disease: Leprosy, Susceptibility To, 3; Mycobacterium Tuberculosis, Susceptibility To

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage