product summary
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company name :
MyBioSource
product type :
antibody
product name :
CD33 Monoclonal Antibody
catalog :
MBS668002
quantity :
0.1 mg
price :
175 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
[ABM29D3]
reactivity :
human
application :
western blot, immunohistochemistry, FACS
more info or order :
product information
catalog number :
MBS668002
products type :
Antibody
products full name :
CD33 Monoclonal Antibody
products short name :
[CD33 ]
other names :
[myeloid cell surface antigen CD33 isoform 2; Myeloid cell surface antigen CD33; myeloid cell surface antigen CD33; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; CD33 molecule; Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD_antigen: CD33]
products gene name :
[CD33 ]
other gene names :
[CD33; CD33; p67; SIGLEC3; SIGLEC-3; SIGLEC3; Siglec-3]
uniprot entry name :
CD33_HUMAN
clonality :
Monoclonal
isotype :
Mouse IgG2a, Kappa
clone :
[ABM29D3]
host :
Mouse
reactivity :
Human
sequence length :
237
form :
Purified (Liquid)
concentration :
0.5 mg/ml, 200 µl
storage stability :
Store antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Fluorescence-activated cell sorting (FACS)
app notes :
Western blot analysis: 2-4 ug/ml. Immunohistochemical analysis: 5 ug/ml. FACS: 0.2-0.5 ug/10 6 cells
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Immunohistochemistry (IHC) (IHC)
image4 heading :
Immunohistochemistry (IHC)
image4 description :
Immunohistochemical analysis of CD33 in squamous cell carcinoma of esophagus using CD33 antibody (Clone: ABM29D3) at 5 ug/ml.
image5 heading :
Flow Cytometry
image5 description :
Cell Surface flow analysis of hCD33 in PBMC (Monocytes) using 0.2?g/10^6 cells of CD33 clone (ABM29D3). Green represents isotype control; red represents antihCD33 antibody. Goat anti-mouse PE conjugated secondary antibody was used.
other info1 :
Antigen: CD33
other info2 :
Immunogen: A partial recombinant CD33 protein (amino acids 28-320) was used as the immunogen for this antibody.
products categories :
Immunology
products description :
CD33 is a member of the SIGLEC (Sialic Acid-Binding Ig-Like Lectin) family of receptors, and the gene comprises seven coding
exons. Exon 2 encodes the canonical IgV domain, exon 4 encodes the IgC structural domain, and exons 6 and 7 encode
cytosolic ITIMs (Immunotyrosine Inhibitory Motifs). CD33 acts as a cell surface antigen which is expressed on normal myeloid
cells and CD34+ blasts in AML (Acute Myeloid Leukemia). The antigen serves as a target of GO (Gemtuzumab/Ozogamicin),
which exerts anti-leukemic effects in refractory AML.
ncbi gi num :
130980072
ncbi acc num :
NP_001076087.1
ncbi gb acc num :
NM_001082618.1
uniprot acc num :
P20138
ncbi pathways :
Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489)
uniprot summary :
CD33: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Protein type: Membrane protein, integral; Cell adhesion. Chromosomal Location of Human Ortholog: 19q13.3. Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane. Molecular Function: protein binding; receptor activity; carbohydrate binding. Biological Process: negative regulation of cell proliferation; cell-cell signaling; signal transduction; cell adhesion
size1 :
0.1 mg
price1 :
175 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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