protein

Retinol-binding protein 4 (RBP4) from human plasma,

MBS664077

0.1 mg

355 USD

Protein

Retinol-binding protein 4 (RBP4) from human plasma,

Retinol-binding protein

retinol-binding protein 4; Retinol-binding protein 4; retinol-binding protein 4; RBP; PRBP; plasma retinol-binding protein; retinol-binding protein 4, interstitial; retinol binding protein 4, plasma; Plasma retinol-binding protein; PRBP; RBP

RBP4

RBP4; RBP4; RDCCAS; PRBP; RBP

RET4_HUMAN

201

Affinity chromatography and size-exclusion chromatography

Lyophilized from phosphate-buffered saline (10 mM K-phosphate, pH 7.4, 150 mM NaCl). Product is recommended to reconstitute with deionised water

At -20 degree C

Calibrator in immunoassays

Source Note: Pooled human plasma. Donor blood samples were tested and found negative for HBsAg, HIV-1 and HIV-2 antibodies, and HCV. Immunological Activity: Immunoreactivity is checked using monoclonal antibodies specific to RBP4

Analysis: Purity > 95 % (SDS-PAGE)

Search Retinol-binding protein 4 references from PubMed.

55743122

NP_006735.2

NM_006744.3

23,010 Da

Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); Retinoid Cycle Disease Events Pathway (771582); Retinoid Metabolism And Transport Pathway (187208); SREBP Signalling Pathway (219802); Signal Transduction Pathway (477114); The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway (771585); Visual Phototransduction Pathway (771584); Vitamin A And Carotenoid Metabolism Pathway (198785); Retinoate Biosynthesis I Pathway (545452)

This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]

RBP4: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency). This condition causes night vision problems. It produces a typical fundus xerophthalmicus , featuring a progressed atrophy of the retinal pigment epithelium. Belongs to the calycin superfamily. Lipocalin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 10q23.33. Cellular Component: extracellular space; protein complex; extracellular region; cytosol. Molecular Function: protein binding; protein heterodimerization activity; retinol binding; retinal binding. Biological Process: phototransduction, visible light; retinal metabolic process; maintenance of gastrointestinal epithelium; embryonic skeletal development; heart development; glucose homeostasis; uterus development; response to insulin stimulus; embryonic organ morphogenesis; retinol metabolic process; negative regulation of cardiac muscle cell proliferation; detection of light stimulus involved in visual perception; retinoid metabolic process; female genitalia morphogenesis; cardiac muscle development; response to retinoic acid; urinary bladder development; male gonad development; vagina development; positive regulation of insulin secretion; positive regulation of immunoglobulin secretion; gluconeogenesis; response to ethanol; eye development; embryonic retina morphogenesis in camera-type eye; spermatogenesis; lung development. Disease: Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome; Microphthalmia, Isolated, With Coloboma 10

0.1 mg

355 USD

0.5 mg

605

1 mg

815