catalog number :
MBS660254
products full name :
Monoclonal mouse anti-soluble CD40 ligand (sCD40L)
products short name :
sCD40L
other names :
CD40 ligand; CD40 ligand; CD40 ligand; CD40-L; CD40 antigen ligand; T-cell antigen Gp39; T-B cell-activating molecule; TNF-related activation protein; tumor necrosis factor (ligand) superfamily member 5; CD40 ligand; T-cell antigen Gp39; TNF-related activation protein; TRAP; Tumor necrosis factor ligand superfamily member 5; CD_antigen: CD154Cleaved into the following 2 chains:CD40 ligand, membrane form; CD40 ligand, soluble form
products gene name :
sCD40L
other gene names :
CD40LG; CD40LG; IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L; CD40L; TNFSF5; TRAP; CD40-L; TRAP
uniprot entry name :
CD40L_HUMAN
isotype :
IgG1 for all MAbs
clone :
30B4; New MAbs: 1H4, 2A3, 2B10, 10A6
specificity :
Human recombinant sCD40L
purity :
Chromatography on protein A Sepharose
form :
PBS, pH 7.4, 0.1 % sodium azide (NaN3)
storage stability :
4 degree C
tested application :
Western Blot (WB)
app notes :
Human sCD40L immunoassay. All MAbs work in enzyme immunoassays. MAbs can be used for detection of human sCD40L in serum. All MAbs work in Western blotting, but for best sensitivity we recommend MAbs 2B10 and 30B4. Recommended pairs for sandwich immunoassay for detection of native sCD40L in human serum (capture-detection):. 1H4 - 2A3. 10A6 - 2A3. 30B4 - 2A3.
other info1 :
Clone Note: Hybridoma clones have been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with recombinant human soluble CD40 Ligand / TRAP Analog conjugates with BSA.
ncbi acc num :
NP_000065.1
ncbi gb acc num :
NM_000074.2
ncbi mol weight :
29,274 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Allograft Rejection Pathway 920963!!Allograft Rejection Pathway 83123!!Allograft Rejection Pathway 535!!Asthma Pathway 83120!!Asthma Pathway 532!!Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533!!CD40/CD40L Signaling Pathway 138061!!Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway 137993
ncbi summary :
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]