product summary
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company name :
MyBioSource
product type :
antibody
product name :
Monoclonal mouse anti-FK506 (Tacrolimus)
catalog :
MBS660183
quantity :
1 mg
price :
620 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
FK1
application :
ELISA, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS660183
products type :
Antibody
products full name :
Monoclonal mouse anti-FK506 (Tacrolimus)
products short name :
FK 506
other names :
FK-506 binding protein homologue
products gene name :
FK506
clonality :
Monoclonal
isotype :
IgM for MAb FK1
clone :
FK1
sequence length :
355
purity :
Euglobulin precipitation and dialysis.
form :
50 mM Tris/HCl, 150 mM NaCl, pH 8.0, 0.1 % sodium azide (NaN3)
concentration :
4.6 mg/ml. Volume: 1 x 0.220ml
storage stability :
4 degree C
tested application :
ELISA (EIA)
app notes :
Detection of FK-506-antigen in ELISA. FK 506 antigen is a novel macrolide with similar but more potent immunosuppressant activity than cyclosporine. FK 506 is used for primary or rescue immunosuppression in patients after solid organ transplantation. Clinically relevant FK506 side effects are nephrotoxicity, neurotoxicity, diabetes mellitus and hypertension. Most of these side effects are more closely related to FK 506 blood levels than dosage; therefore therapeutic drug monitoring (TDM) of FK506 levels is a prerequisite for therapy. Whole blood is the matrix of choice for FK 506 TDM. The whole blood target level range aimed for in clinical practice is between 3.0 and 20.0 ng/ml and depends on the patient's liver function, the type of organ transplanted and the time after transplantation.
other info1 :
Clone Note: Hybridoma clone has been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with conjugate FK-506-BSA.
other info2 :
Material Safety Note: This product is sold as an antibody preparation for research use only. Standard Laboratory Practices should be followed when handling this material. Contains sodium azide (0.1%) as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
ncbi gi num :
965470
ncbi acc num :
AAB00102.1
uniprot summary :
FKBP8: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Isomerase; Chaperone; Mitochondrial; EC 5.2.1.8. Chromosomal Location of Human Ortholog: 19p12. Cellular Component: endoplasmic reticulum membrane; membrane; mitochondrial membrane; integral to endoplasmic reticulum membrane. Molecular Function: identical protein binding; protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; metal ion binding. Biological Process: smoothened signaling pathway; protein peptidyl-prolyl isomerization; camera-type eye development; viral reproduction; regulation of gene expression; apoptosis; multicellular organism growth; cell fate specification; dorsoventral neural tube patterning; positive regulation of BMP signaling pathway; negative regulation of apoptosis
size1 :
1 mg
price1 :
620 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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