Monoclonal mouse anti-human osteocalcin | MyBioSource MBS660145 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Monoclonal mouse anti-human osteocalcin

catalog :

MBS660145

quantity :

1 mg

price :

630 USD

clonality :

monoclonal

host :

unidentified

conjugate :

nonconjugated

clone name :

[3G7, 1C4, 1C7, 3G8, 8H12, 2H9, 6F9]

reactivity :

human

application :

ELISA

more info or order :

MyBioSource product webpage

image

image 1 :

MAb 2H9 cross-reacts with bovine, rat and pig OC and is not cross-reacting with mouse OC. MAb 6F9 is not cross-reacting with bovine, rat, mouse, rabbit or pig OC. The ability of the MAbs to recognize full length human osteocalcin, tryptic 1-19, 20-43, synthetic 7-19, 15-31 and bovine osteocalcin was tested with Eu-labelled antigens. *MAb 3G8 recognizes unlabelled human osteocalcin (hOC) and bovine osteocalcin (bOC) when tested with two-site combinations

product information

catalog number :

MBS660145

products type :

Antibody

products full name :

Monoclonal mouse anti-human osteocalcin

products short name :

[Osteocalcin]

other names :

[osteocalcin preproprotein; Osteocalcin; osteocalcin; bone Gla protein; gamma-carboxyglutamic acid-containing protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin); bone gamma-carboxyglutamate (gla) protein; Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein]

other gene names :

[BGLAP; BGLAP; OC; BGP; OCN; BGP]

uniprot entry name :

OSTCN_HUMAN

clonality :

Monoclonal

clone :

[3G7, 1C4, 1C7, 3G8, 8H12, 2H9, 6F9]

host :

unknown

sequence length :

100

purity :

Chromatography on protein A Sepharose

form :

PBS, pH 7.4, 0.09 % sodium azide (NaN3) for MAbs 6F9 and 2H9. 0.9 % NaCl, 0.09 % sodium azide (NaN3) for MAbs 3G7, 1C4, 1C7, 3G8 and 8H12

concentration :

6.3 mg/mL

storage stability :

+4°C (+2. 8°C allowed).

tested application :

MAbs are working in ELISA.

app notes :

Recommended pairs are (capture-detection):. 2H9 - 6F9 (detects the large NH2- terminal fragment and intact hOC). 3G8 - 2H9 (detects only the intact hOC)

image1 heading :

Testing Data (TD)

other info1 :

MAbs: 3G7, 1C4, 1C7, 3G8, 2H9, 6F9, 8H12. MAb isotypes: IgG1 for MAbs 1C4, 1C7, 3G8, 6F9, 8H12. IgG2a for MAb 2H9. IgG2b for MAb 3G7. MAb Specifications: MAb: 3G8. Concentration: 2.0 mg/ml. MAb: 2H9. Concentration: 5.9 mg/ml. MAb: 6F9. Concentration: 6.3mg/ml. MAb: 8H12. Concentration: 1.7 mg/ml

other info2 :

Material Safety Note: This product is sold for research use only. Standard Laboratory Practices should be followed when handling this material. Product contains sodium azide as a preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product

ncbi gi num :

40316933

ncbi acc num :

NP_954642.1

ncbi gb acc num :

NM_199173.4

ncbi pathways :

FGF Signaling Pathway (137989); Glucocorticoid Receptor Regulatory Network Pathway (138014); Interleukin-11 Signaling Pathway (698753); Notch-mediated HES/HEY Network Pathway (169347); Regulation Of Retinoblastoma Protein Pathway (137916); Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway (169349)

ncbi summary :

This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]

uniprot summary :

osteocalcin: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Belongs to the osteocalcin/matrix Gla protein family. Protein type: Secreted, signal peptide; Secreted; Cell development/differentiation. Chromosomal Location of Human Ortholog: 1q22. Cellular Component: Golgi apparatus; extracellular space; rough endoplasmic reticulum; dendrite; cytoplasm; perikaryon. Molecular Function: structural constituent of bone; hydroxyapatite binding; calcium ion binding; structural molecule activity. Biological Process: response to drug; response to gravity; regulation of bone resorption; response to glucocorticoid stimulus; cell aging; response to testosterone stimulus; bone mineralization; osteoblast development; osteoblast differentiation; odontogenesis; regulation of osteoclast differentiation; response to vitamin D; response to ethanol; response to vitamin K; response to mechanical stimulus; response to estrogen stimulus; response to zinc ion; response to hydroxyisoflavone; response to activity; cell adhesion; regulation of bone mineralization; skeletal development

size1 :

1 mg

price1 :

630 USD

size2 :

5 mg

price2 :

2645

size3 :

10 mg

price3 :

5060

size4 :

15 mg

price4 :

7390

more info or order :

MyBioSource product webpage