product summary
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company name :
MyBioSource
product type :
protein
product name :
Endothelin 1 (Big) (1-39) (human)
catalog :
MBS659983
quantity :
1 mg
price :
820 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS659983
products type :
Peptide
products full name :
Endothelin 1 (Big) (1-39) (human)
products short name :
Endothelin 1
other names :
endothelin-1; Endothelin-1; endothelin-1; preproendothelin-1; endothelin 1; Preproendothelin-1
other gene names :
EDN1; EDN1; ET1; PPET1; HDLCQ7; PPET1; ET-1
uniprot entry name :
EDN1_HUMAN
host :
Synthetic peptide
reactivity :
Human
sequence :
Sequence (linear): Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser
purity :
Highly Purified. ~95%. Purified by HPLC.
form :
Supplied as a lyophilized powder
storage stability :
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
other info1 :
Molecular Formula: C189 H286 N48 O56 S5
other info2 :
Warning: It is practically impossible to recover a peptide that has aggregated in the presence of salt. If sufficient peptide is available, test the solubility on a small sample first. Please not that DMSO can completely oxidize the free thiol groups of cysteine in short-chain peptides within minutes and should be avoided as a solvent for these peptides. Peptides containing Trp, Met, Cys, Asn or Gln require special car to avoid oxidation; oxygen free water should be used.
products categories :
Molecular Biology; MB-Peptides
products description :
Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms, ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart and liver.
ncbi gi num :
556203
ncbi acc num :
AAA52339.1
uniprot acc num :
P05305
ncbi mol weight :
4286.96
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway (106357); EGFR-dependent Endothelin Signaling Events Pathway (138037); Endothelin Pathway (672453); Endothelins Pathway (137958); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); HIF-1 Signaling Pathway (695200); HIF-1-alpha Transcription Factor Network Pathway (138045)
ncbi summary :
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
uniprot summary :
Function: Endothelins are endothelium-derived vasoconstrictor peptides. Subcellular location: Secreted. Tissue specificity: Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells. Ref.11. Sequence similarities: Belongs to the endothelin/sarafotoxin family.
size1 :
1 mg
price1 :
820 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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